دانلود مقاله ISI انگلیسی شماره 69744
عنوان فارسی مقاله

سندرم استرس شبیه مزمن به عنوان یک نتیجه از تحریک ساب‌تالامیک سایت میانی در بیماری پارکینسون

کد مقاله سال انتشار مقاله انگلیسی ترجمه فارسی تعداد کلمات
69744 2015 9 صفحه PDF سفارش دهید محاسبه نشده
خرید مقاله
پس از پرداخت، فوراً می توانید مقاله را دانلود فرمایید.
عنوان انگلیسی
Chronic stress-like syndrome as a consequence of medial site subthalamic stimulation in Parkinson's disease
منبع

Publisher : Elsevier - Science Direct (الزویر - ساینس دایرکت)

Journal : Psychoneuroendocrinology, Volume 52, February 2015, Pages 302–310

کلمات کلیدی
تحریک عمقی مغز؛ کورتیزول؛ هسته ساب‌تالامیک ؛ فشار؛ افزایش وزن؛ اضطراب
پیش نمایش مقاله
پیش نمایش مقاله سندرم استرس شبیه مزمن به عنوان یک نتیجه از تحریک ساب‌تالامیک سایت میانی در بیماری پارکینسون

چکیده انگلیسی

Considering the functional organization of the subthalamic nucleus (STN), we hypothesized that subthalamic deep brain stimulation (STN-DBS) in Parkinson's disease might have a differential impact on the hypothalamic-pituitary-adrenal axis in relation to the position of active stimulating contact within the STN. In addition, we searched for any STN-DBS-related morning plasma cortisol changes in association with postoperative anxiety and weight gain. A plasma cortisol measurement was performed on the day of initiation of bilateral STN-DBS and repeated after 1 and 17 months in twenty patients with advanced Parkinson's disease. The body weight change and anxiety scores following the implantation were assessed as well. The electrode positions in the STN were determined on T1-weighted magnetic resonance images. After initiation of stimulation, cortisol levels significantly decreased and the cortisol changes after 1 and 17 months strongly correlated with the position of active contact in the subthalamic area. Patients with at least one contact located more medially in the STN experienced a significantly greater decrease of cortisol than those with one or both active contacts more laterally. Furthermore, the lower cortisol levels were strongly associated with higher trait anxiety and weight gain. These changes mimicked the effects of chronic stress and suggest the disturbing impact of STN-DBS on limbic and motivational systems.

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پس از پرداخت، فوراً می توانید مقاله را دانلود فرمایید.