دانلود مقاله ISI انگلیسی شماره 69754
عنوان فارسی مقاله

اختلال ملال پیش از قاعدگی و واکنش بجلو مغز در طول پیش بینی محرک های عاطفی

کد مقاله سال انتشار مقاله انگلیسی ترجمه فارسی تعداد کلمات
69754 2013 10 صفحه PDF سفارش دهید محاسبه نشده
خرید مقاله
پس از پرداخت، فوراً می توانید مقاله را دانلود فرمایید.
عنوان انگلیسی
Premenstrual dysphoric disorder and prefrontal reactivity during anticipation of emotional stimuli
منبع

Publisher : Elsevier - Science Direct (الزویر - ساینس دایرکت)

Journal : European Neuropsychopharmacology, Volume 23, Issue 11, November 2013, Pages 1474–1483

کلمات کلیدی
اختلال ملال پیش از قاعدگی؛ پروژسترون؛ استروژن؛ پیش بینی؛ هیجان؛
پیش نمایش مقاله
پیش نمایش مقاله اختلال ملال پیش از قاعدگی و واکنش بجلو مغز در طول پیش بینی محرک های عاطفی

چکیده انگلیسی

Premenstrual disorder (PMDD) affects around 5% of women in childbearing ages. An increased sensitivity in emotion processing areas of the brain to variations in ovarian steroid levels has been suggested as part of the pathophysiology in PMDD, but prior neuroimaging studies of emotion processing are yet inconclusive. Previous behavioral studies of women with PMDD have, however, reported enhanced luteal phase startle responsivity during emotional anticipation. Here we used functional magnetic resonance imaging (fMRI) to investigate central neural circuitry activity during anticipation of, and exposure to, emotional stimuli across the menstrual cycle in women with and without PMDD. As compared to healthy controls, women with PMDD displayed significantly enhanced reactivity in the prefrontal cortex during anticipation of, but not exposure to, negative emotional stimuli during the luteal phase. In PMDD patients, BOLD reactivity during anticipation or viewing of negative emotional stimuli was not dependent on absolute levels of estradiol or progesterone. However, progesterone levels were positively correlated with emotion-induced reactivity in the dorsolateral prefrontal cortex to positive emotional stimuli. These findings suggest that cortical emotional circuitry reactivity during anticipation is altered in PMDD during the luteal phase, which might be part of the pathophysiology behind the emotional symptoms or lack of emotional control reported by women with PMDD.

خرید مقاله
پس از پرداخت، فوراً می توانید مقاله را دانلود فرمایید.