دانلود مقاله ISI انگلیسی شماره 69807
عنوان فارسی مقاله

تاریخ سوء استفاده جنسی با اثرات مختلف کلونیدین بر عملکرد اتونوم در زنان مبتلا به اختلال ملال پیش از قاعدگی در ارتباط است

کد مقاله سال انتشار مقاله انگلیسی ترجمه فارسی تعداد کلمات
69807 2005 16 صفحه PDF سفارش دهید محاسبه نشده
خرید مقاله
پس از پرداخت، فوراً می توانید مقاله را دانلود فرمایید.
عنوان انگلیسی
Histories of sexual abuse are associated with differential effects of clonidine on autonomic function in women with premenstrual dysphoric disorder
منبع

Publisher : Elsevier - Science Direct (الزویر - ساینس دایرکت)

Journal : Biological Psychology, Volume 69, Issue 3, July 2005, Pages 281–296

کلمات کلیدی
اختلال ملال پیش از قاعدگی؛ سوء استفاده جنسی؛ کلونیدین؛ سیستم عصبی سمپاتیک؛ عملکرد آدرنرژیک
پیش نمایش مقاله
پیش نمایش مقاله تاریخ سوء استفاده جنسی با اثرات مختلف کلونیدین بر عملکرد اتونوم در زنان مبتلا به اختلال ملال پیش از قاعدگی در ارتباط است

چکیده انگلیسی

In women meeting strict criteria for premenstrual dysphoric disorder (PMDD), we examined whether clonidine, an α2-adrenergic receptor (AR) agonist, would have different effects on sexually abused versus non-abused PMDD women for measures of autonomic nervous system function. Twelve women meeting prospective, DSM-IV criteria for PMDD, five of whom had a history of sexual abuse, participated in a randomized, placebo-controlled, double-blind, cross-over design study, comparing 2 months of on oral clonidine (0.3 mg/day) with 2 months on active placebo. During the luteal phase that preceded randomization and following each two-month challenge, women were tested for cardiovascular measures at rest and in response to mental stress, and for resting plasma norepinephrine (NE) concentrations as well as β1 and β2-AR responsivity using the isoproterenol sensitivity test. Results revealed that in comparison to placebo, clonidine significantly reduced plasma norepinephrine concentrations, increased both β1- and β2-AR responsivity, and reduced resting and stress heart rate (HR) and blood pressure (BP) (p < 0.05) in all PMDD women. With clonidine, sexually abused PMDD women exhibited greater decreases in resting and stress-induced HR (p < 0.01) and stress-induced systolic BP (p < 0.05), while non-abused PMDD women exhibited greater reductions in plasma NE concentration (p = 0.07), and greater increases in β2-AR responsivity (p < 0.05) than abused PMDD women. These results suggest PMDD women with and without a history of sexual abuse respond differently to a clonidine challenge in measures reflecting autonomic nervous system functioning, indicating that abuse may modify presynaptic α2-AR function in PMDD.

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پس از پرداخت، فوراً می توانید مقاله را دانلود فرمایید.