دانلود مقاله ISI انگلیسی شماره 69839
عنوان فارسی مقاله

تاریخ افسردگی اساسی و اختلال ملال پیش از قاعدگی: شواهد برای تفاوت فنوتیپی

کد مقاله سال انتشار مقاله انگلیسی ترجمه فارسی تعداد کلمات
69839 2010 13 صفحه PDF سفارش دهید محاسبه نشده
خرید مقاله
پس از پرداخت، فوراً می توانید مقاله را دانلود فرمایید.
عنوان انگلیسی
Histories of major depression and premenstrual dysphoric disorder: Evidence for phenotypic differences
منبع

Publisher : Elsevier - Science Direct (الزویر - ساینس دایرکت)

Journal : Biological Psychology, Volume 84, Issue 2, May 2010, Pages 235–247

کلمات کلیدی
PMDD؛ داستان افسردگی؛ سیستم عصبی سمپاتیک؛ محور هیپوتالاموس هیپوفیز آدرنال؛ درد
پیش نمایش مقاله
پیش نمایش مقاله تاریخ افسردگی اساسی و اختلال ملال پیش از قاعدگی: شواهد برای تفاوت فنوتیپی

چکیده انگلیسی

This study examined unique versus shared stress and pain-related phenotypes associated with premenstrual dysphoric disorder (PMDD) and prior major depressive disorder (MDD). Sympathetic nervous system (SNS) and hypothalamic–pituitary–adrenal (HPA)-axis measures were assessed at rest and during mental stress, as well as sensitivity to cold pressor and tourniquet ischemic pain tasks in four groups of women: (1) non-PMDD with no prior MDD (N = 18); (2) non-PMDD with prior MDD (N = 9); (3) PMDD with no prior MDD (N = 17); (4) PMDD with prior MDD (N = 10). PMDD women showed blunted SNS responses to stress compared to non-PMDD women, irrespective of prior MDD; while women with prior MDD showed exaggerated diastolic blood pressure responses to stress versus never depressed women, irrespective of PMDD. However, only in women with histories of MDD did PMDD women have lower cortisol concentrations than non-PMDD women, and only in non-PMDD women was MDD associated with reduced cold pressor pain sensitivity. These results suggest both unique phenotypic differences between women with PMDD and those with a history of MDD, but also indicate that histories of MDD may have special relevance for PMDD.

خرید مقاله
پس از پرداخت، فوراً می توانید مقاله را دانلود فرمایید.