دانلود مقاله ISI انگلیسی شماره 71182
عنوان فارسی مقاله

نظارت بر عملکرد حافظه و فعالیت PFC با ژنوتیپ 5 HTTLPR در بزرگسالان مسن تر در ارتباط است

کد مقاله سال انتشار مقاله انگلیسی ترجمه فارسی تعداد کلمات
71182 2012 14 صفحه PDF سفارش دهید محاسبه نشده
خرید مقاله
پس از پرداخت، فوراً می توانید مقاله را دانلود فرمایید.
عنوان انگلیسی
Memory monitoring performance and PFC activity are associated with 5-HTTLPR genotype in older adults
منبع

Publisher : Elsevier - Science Direct (الزویر - ساینس دایرکت)

Journal : Neuropsychologia, Volume 50, Issue 9, July 2012, Pages 2257–2270

کلمات کلیدی
پیری - fMRI؛ نظارت بر حافظه؛ فراحافظه ؛ قشر جلوی مغز؛ سروتونین
پیش نمایش مقاله
پیش نمایش مقاله نظارت بر عملکرد حافظه و فعالیت PFC با ژنوتیپ 5 HTTLPR در بزرگسالان مسن تر در ارتباط است

چکیده انگلیسی

Older adults show extensive variability in cognitive performance, including episodic memory. A portion of this variability could potentially be explained by genetic factors. Recent literature shows that the neurotransmitter serotonin plays an important role in memory processes, as enhancements of brain serotonin have led to memory improvement. Here, we have begun to explore genetic contributions to the performance and underlying brain activity associated with source memory monitoring. Using a source recognition memory task during fMRI scanning, this study offers evidence that older adults who carry a short allele (S-car) of the serotonin transporter linked polymorphic region (5-HTTLPR) in the SLC6A4 gene show specific deficits in source memory monitoring relative to older adults who are homozygous for the long allele (LL). These deficits are accompanied by less neural activity in regions of prefrontal cortex that have been shown to support accurate memory monitoring. Moreover, while the older adult LL group's behavioral performance does not differ from younger adults, their brain activation reveals evidence of compensatory activation that likely supports their higher performance level. These results provide preliminary evidence that the long-allele homozygous profile is cognitively beneficial to older adults, particularly for memory functioning.

خرید مقاله
پس از پرداخت، فوراً می توانید مقاله را دانلود فرمایید.