دانلود مقاله ISI انگلیسی شماره 71394
عنوان فارسی مقاله

عملکرد حافظه انجمنی چهره نام به بار آمیلوئید در سالمندان عادی مرتبط است

کد مقاله سال انتشار مقاله انگلیسی ترجمه فارسی تعداد کلمات
71394 2011 8 صفحه PDF سفارش دهید محاسبه نشده
خرید مقاله
پس از پرداخت، فوراً می توانید مقاله را دانلود فرمایید.
عنوان انگلیسی
Face-name associative memory performance is related to amyloid burden in normal elderly
منبع

Publisher : Elsevier - Science Direct (الزویر - ساینس دایرکت)

Journal : Neuropsychologia, Volume 49, Issue 9, July 2011, Pages 2776–2783

کلمات کلیدی
بیماری بالینی آلزایمر؛ تشخیص زود هنگام؛ پیری طبیعی؛ تصویربرداری آمیلوئید
پیش نمایش مقاله
پیش نمایش مقاله عملکرد حافظه انجمنی چهره نام به بار آمیلوئید در سالمندان عادی مرتبط است

چکیده انگلیسی

Cerebral amyloid beta (Aβ) deposition occurs in a substantial fraction of cognitively normal (CN) older individuals. However, it has been difficult to reliably detect evidence of amyloid-related cognitive alterations in CN using standard neuropsychological measures. We sought to determine whether a highly demanding face-name associative memory exam (FNAME) could detect evidence of Aβ-related memory impairment in CN. We studied 45 CN subjects (mean age = 71.7 ± 8.8) with Clinical Dementia Rating (CDR) scores = 0 and MMSE ≥ 28, using Positron Emission Tomography with Pittsburgh Compound B (PiB PET). Memory factor scores were derived from a principal components analysis for FNAME name retrieval (FN-N), FNAME occupation retrieval (FN-O) and the 6-Trial Selective Reminding Test (SRT). Using multiple linear and logistic regression analyses, we related the memory factor scores to PiB distribution volume ratios (DVR, cerebellar reference) as either a continuous or a dichotomous variable in frontal cortex and a posterior cortical region representing the precuneus, posterior cingulate and lateral parietal cortices (PPCLP), co-varying for age and AMNART IQ (a proxy of cognitive reserve (CR)). A significant inverse relationship for FN-N was found with Aβ deposition in frontal (R2 = 0.29, β = −2.2, p = 0.02) and PPCLP cortices (R2 = 0.26, β = −2.4, p = 0.05). In contrast, neither FN-O nor the SRT were significantly related to Aβ deposition. Performance on a demanding test of face-name associative memory was related to Aβ burden in brain regions associated with memory systems. Associative memory for faces and names, a common complaint among older adults, may be a sensitive marker of early Aβ-related impairment.

خرید مقاله
پس از پرداخت، فوراً می توانید مقاله را دانلود فرمایید.