دانلود مقاله ISI انگلیسی شماره 71400
عنوان فارسی مقاله

بکارگیری ترجیحی آمیگدال بازولترال در طول رمزگذاری حافظه از صحنه های منفی در اختلال استرس پس از سانحه

کد مقاله سال انتشار مقاله انگلیسی ترجمه فارسی تعداد کلمات
71400 2016 7 صفحه PDF سفارش دهید محاسبه نشده
خرید مقاله
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عنوان انگلیسی
Preferential recruitment of the basolateral amygdala during memory encoding of negative scenes in posttraumatic stress disorder
منبع

Publisher : Elsevier - Science Direct (الزویر - ساینس دایرکت)

Journal : Neurobiology of Learning and Memory, Volume 130, April 2016, Pages 170–176

کلمات کلیدی
آمیگدال؛ آمیگدال بازولترال ؛ حافظه؛ هیجانی؛ fMRI؛ اختلال استرس بعد از سانحه
پیش نمایش مقاله
پیش نمایش مقاله بکارگیری ترجیحی آمیگدال بازولترال در طول رمزگذاری حافظه از صحنه های منفی در اختلال استرس پس از سانحه

چکیده انگلیسی

Background: The vast majority of functional neuroimaging studies in posttraumatic stress disorder (PTSD) have examined the amygdala as a unitary structure. However, an emerging body of studies indicates that separable functions are subserved by discrete amygdala subregions. The basolateral subdivision (BLA), as compared with the centromedial amygdala (CMA), plays a unique role in learning and memory-based processes for threatening events, and alterations to the BLA have been implicated in the pathogenesis of PTSD. We assessed whether PTSD is associated with differential involvement of the BLA versus the CMA during successful encoding of emotionally charged events. Methods: Participants with PTSD (n = 11) and a trauma-exposed comparison (TEC) group (n = 11) viewed a series of photos that varied in valence (negative versus positive) and arousal (high versus low) while undergoing functional magnetic resonance imaging (fMRI). Subsequently, participants completed an old/new recognition memory test. Results: Using analytic methods based on probabilistic cytoarchitectonic mapping, PTSD was associated with greater activation of the BLA, as compared to the CMA, during successful encoding of negative scenes, a finding which was not observed in the TEC group. Moreover, this memory-related activity in the BLA independently predicted PTSD status. Contrary to hypotheses, there was no evidence of altered BLA activity during memory encoding of high arousing relative to low arousing scenes. Conclusions: Task-related brain activation in PTSD does not appear to be consistent across the entire amygdala. Importantly, memory-related processing of negative information in PTSD is associated with preferential recruitment of the BLA.

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