دانلود مقاله ISI انگلیسی شماره 71417
عنوان فارسی مقاله

ارتباطات عصبی بازیابی از اختلال استرس پس از سانحه: مطالعه fMRI طولی از رمزگذاری حافظه

کد مقاله سال انتشار مقاله انگلیسی ترجمه فارسی تعداد کلمات
71417 2011 8 صفحه PDF سفارش دهید محاسبه نشده
خرید مقاله
پس از پرداخت، فوراً می توانید مقاله را دانلود فرمایید.
عنوان انگلیسی
Neural correlates of recovery from post-traumatic stress disorder: A longitudinal fMRI investigation of memory encoding
منبع

Publisher : Elsevier - Science Direct (الزویر - ساینس دایرکت)

Journal : Neuropsychologia, Volume 49, Issue 7, June 2011, Pages 1771–1778

کلمات کلیدی
اختلال استرس پس از سانحه؛ تصویربرداری رزونانس مغناطیسی عملکردی؛ بهبود؛ آمیگدال؛ قشر جلوی مغز میانی؛ هیپوکامپ
پیش نمایش مقاله
پیش نمایش مقاله ارتباطات عصبی بازیابی از اختلال استرس پس از سانحه: مطالعه fMRI طولی از رمزگذاری حافظه

چکیده انگلیسی

Post-traumatic stress disorder (PTSD) is characterized by a failure of psychological recovery from a traumatic experience. At a neural level, it is associated with abnormalities of the areas of the neural system that process threatening information, including the amygdala and medial-prefrontal cortex, as well as of that involved in episodic memory, including the hippocampus. However, little is known about how the function of these regions may change as one recovers from the disorder. In this investigation, PTSD patients underwent two functional magnetic resonance imaging (fMRI) scans, 6–9 months apart, while viewing fearful and neutral faces in preparation for a memory test (administered outside the scanner). At Time 2, 65% of patients were in remission. Current symptom levels correlated positively with memory-related fMRI activity in the amygdala and ventral-medial prefrontal cortex (vmPFC). In addition, the change in activity within the hippocampus and the subgenual anterior cingulate cortex (sgACC) was associated with the degree of symptom improvement (n = 18). These results suggest differential involvement of structures within the fear network in symptom manifestation and in recovery from PTSD: whereas activity within the amygdala and vmPFC appeared to be a marker of current symptom severity, functional changes in the hippocampus and sgACC reflected recovery. These results underscore the importance of longitudinal investigations for the identification of the differential neural structures associated with the expression and remission of anxiety disorders.

خرید مقاله
پس از پرداخت، فوراً می توانید مقاله را دانلود فرمایید.