دانلود مقاله ISI انگلیسی شماره 71418
عنوان فارسی مقاله

بهره وری رمزگذاری حافظه کار در دوقلوهای ناهمسان برای اسکیزوفرنی

کد مقاله سال انتشار مقاله انگلیسی ترجمه فارسی تعداد کلمات
71418 2009 8 صفحه PDF سفارش دهید محاسبه نشده
خرید مقاله
پس از پرداخت، فوراً می توانید مقاله را دانلود فرمایید.
عنوان انگلیسی
Efficiency of working memory encoding in twins discordant for schizophrenia ☆
منبع

Publisher : Elsevier - Science Direct (الزویر - ساینس دایرکت)

Journal : Psychiatry Research: Neuroimaging, Volume 174, Issue 2, 30 November 2009, Pages 97–104

کلمات کلیدی
الکتروفیزیولوژی؛ ERP؛ عملکرد؛
پیش نمایش مقاله
پیش نمایش مقاله بهره وری رمزگذاری حافظه کار در دوقلوهای ناهمسان برای اسکیزوفرنی

چکیده انگلیسی

It has been proposed that patients with schizophrenia and some of their relatives suffer from reduced neurocognitive efficiency, increasing their sensitivity to experimental task demands. The present study evaluated such a possibility during performance of a working memory task by schizophrenia patients and their co-twins along with a healthy control sample. Electrophysiological data were obtained from sets of nine twin pairs (monozygotic and dizygotic pairs collapsed) discordant for a diagnosis of schizophrenia and from nine matched healthy control twin pairs, during administration of a variable-load spatial working memory task. Event-related potentials (ERPs) were measured immediately after memory set onset and during a delay period. For correctly performed trials, slow-wave ERP activity measured during the late stimulus encoding and delay periods exhibited a significant Diagnostic Group-by-Memory Load interaction, with schizophrenia patients showing a differentially strong load effect. Patients' co-twins displayed an intermediate level of load sensitivity while healthy controls showed no significant load effect. These results support an inefficiency model of neurocognitive dysfunction in schizophrenia, a pattern that appears to be related to the pathogenesis and inheritance of the disorder. Furthermore, this inefficiency appeared during the late stimulus encoding stage of working memory functioning, possibly reflecting disruptions in stimulus representation consolidation.

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