دانلود مقاله ISI انگلیسی شماره 71426
عنوان فارسی مقاله

رمزگذاری حافظه و شبکه های تشخیص جدید/آشنایی مبتنی بر هیپوکامپ

کد مقاله سال انتشار مقاله انگلیسی ترجمه فارسی تعداد کلمات
71426 2003 9 صفحه PDF سفارش دهید محاسبه نشده
خرید مقاله
پس از پرداخت، فوراً می توانید مقاله را دانلود فرمایید.
عنوان انگلیسی
Memory encoding and hippocampally-based novelty/familiarity discrimination networks
منبع

Publisher : Elsevier - Science Direct (الزویر - ساینس دایرکت)

Journal : Neuropsychologia, Volume 41, Issue 3, 2003, Pages 271–279

کلمات کلیدی
رمزگذاری حافظه؛ تبعیض تازگی؛ توموگرافی گسیل پوزیترون؛ اتصال عملکردی؛ حداقل مربعات جزئی
پیش نمایش مقاله
پیش نمایش مقاله رمزگذاری حافظه و شبکه های تشخیص جدید/آشنایی مبتنی بر هیپوکامپ

چکیده انگلیسی

Novelty discrimination refers to the ability to decide whether information is new or has been previously encountered. Recent functional neuroimaging work has demonstrated that the hippocampus plays an important function in novelty discrimination. In the study described here, we explored the idea that novelty discrimination does not depend on the hippocampus alone but involves large-scale functional neural networks consisting of spatially remote brain regions. We measured blood flow with positron emission tomography (PET) while subjects semantically encoded visually and auditorily presented situationally novel and familiar words. Following each PET scan, subjects’ memory was tested with a standard yes/no recognition test. Blood flow data were analyzed with the covariance-based seed partial least squares (PLS) method. Behaviorally, subjects’ recognition performance was higher for novel than familiar words. Neurally, two large-scale functional networks involving the same region of the hippocampus were identified which showed coherent activity either during the encoding of situationally novel (but not familiar) items or situationally familiar (but not novel) items. These findings indicate that different neural networks are active in the processing of situationally novel and familiar information. The observation that the hippocampus participates in both networks supports the principle of neural context.

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