دانلود مقاله ISI انگلیسی شماره 71439
عنوان فارسی مقاله

چرخش ذهنی در پسران با استعداد توسط گیرنده های آندروژن پلی مورفیسم تکراری CAG تحت تاثیر قرار می گیرد

کد مقاله سال انتشار مقاله انگلیسی ترجمه فارسی تعداد کلمات
71439 2013 6 صفحه PDF سفارش دهید محاسبه نشده
خرید مقاله
پس از پرداخت، فوراً می توانید مقاله را دانلود فرمایید.
عنوان انگلیسی
Mental rotation in intellectually gifted boys is affected by the androgen receptor CAG repeat polymorphism
منبع

Publisher : Elsevier - Science Direct (الزویر - ساینس دایرکت)

Journal : Neuropsychologia, Volume 51, Issue 9, August 2013, Pages 1693–1698

کلمات کلیدی
چرخش ذهنی؛ تستوسترون؛ استعدادهای درخشان ریاضی فکری؛ گیرنده آندروژن
پیش نمایش مقاله
پیش نمایش مقاله چرخش ذهنی در پسران با استعداد توسط گیرنده های آندروژن پلی مورفیسم تکراری CAG تحت تاثیر قرار می گیرد

چکیده انگلیسی

Testosterone was shown to organize brain and modulate cognitive functions. It is currently unknown whether mental rotation is also associated with prenatal testosterone exposure and testosterone-related genetic polymorphisms. The aim of our study was to analyze associations between mental rotation performance, the actual testosterone levels, the prenatal testosterone level (expressed as 2D:4D ratio) and the androgen receptor CAG repeat polymorphism in intellectually gifted boys. One hundred forty-seven boys aged 10–18 years with IQ>130 were enrolled. Saliva samples were collected and used for ELISA of actual levels of salivary testosterone. The 2D:4D finger length ratio as an indicator of prenatal testosterone was measured on both hands and averaged. Amthauer mental rotation test was used for the assessment of this spatial ability. The CAG repeat polymorphism in the androgen receptor gene was analyzed using PCR and capillary electrophoresis. Linear regression revealed that 2D:4D finger length ratio and the number of CAG repeats in the androgen receptor gene were associated with mental rotation. Actual levels of testosterone did not correlate significantly with mental rotation. Multivariate analysis of covariance revealed that after adjustment of age as a confounding variable, only the effect of the genetic polymorphism was significant. The results are in line with our previous genetic analysis of intellectually gifted boys showing the importance of CAG repeat polymorphism in the androgen receptor gene. Details of the interactions between androgen signaling, testosterone levels and its metabolism especially during the prenatal development of brain function remain to be elucidated.

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