دانلود مقاله ISI انگلیسی شماره 71527
عنوان فارسی مقاله

تجویز اندوتوکسین باکتریایی محیطی باعث تحریک هر دو اختلال تثبیت حافظه و بازیابی حافظه در موش ها می شود

کد مقاله سال انتشار مقاله انگلیسی ترجمه فارسی تعداد کلمات
71527 2012 13 صفحه PDF سفارش دهید محاسبه نشده
خرید مقاله
پس از پرداخت، فوراً می توانید مقاله را دانلود فرمایید.
عنوان انگلیسی
Peripheral bacterial endotoxin administration triggers both memory consolidation and reconsolidation deficits in mice
منبع

Publisher : Elsevier - Science Direct (الزویر - ساینس دایرکت)

Journal : Brain, Behavior, and Immunity, Volume 26, Issue 1, January 2012, Pages 109–121

کلمات کلیدی
التهاب؛ سیتوکین؛ حافظه؛ هیپوکامپ؛ زمینه - تثبیت؛ بویایی؛ مجدد
پیش نمایش مقاله
پیش نمایش مقاله تجویز اندوتوکسین باکتریایی محیطی باعث تحریک هر دو اختلال تثبیت حافظه و بازیابی حافظه در موش ها می شود

چکیده انگلیسی

Peripherally administered inflammatory stimuli, such as lipopolysaccharide (LPS), induce the synthesis and release of proinflammatory cytokines and chemokines in the periphery and the central nervous system, and trigger a variety of neurobiological responses. Indeed, prior reports indicate that peripheral LPS administration in rats disrupts contextual fear memory consolidation processes, potentially due to elevated cytokine expression. We used a similar, but partially olfaction-based, contextual fear conditioning paradigm to examine the effects of LPS on memory consolidation and reconsolidation in mice. Additionally, interleukin-1β (IL-1β), brain-derived neurotrophic factor (BDNF), and zinc finger (Zif)-268 mRNA expression in the hippocampus and the cortex, along with peripheral cytokines and chemokines, were assessed. As hypothesized, LPS administered immediately or 2 h, but not 12 h, post-training impaired memory consolidation processes that support the storage of the conditioned contextual fear memory. Additionally, as hypothesized, LPS administered immediately following the fear memory trace reactivation session impaired memory reconsolidation processes. Four hours post-injection, both central cytokine and peripheral cytokine and chemokine levels were heightened in LPS-treated animals, with a simultaneous decrease in BDNF, but not Zif-268, mRNA. Collectively, these data reinforce prior work showing LPS- and cytokine-related effects on memory consolidation, and extend this work to memory reconsolidation.

خرید مقاله
پس از پرداخت، فوراً می توانید مقاله را دانلود فرمایید.