دانلود مقاله ISI انگلیسی شماره 71532
عنوان فارسی مقاله

خواب، تثبیت حافظه انقراض ترس نشانه دار مستقل از فاز تغییرات شبانه روزی را پشتیبانی می کند

کد مقاله سال انتشار مقاله انگلیسی ترجمه فارسی تعداد کلمات
71532 2016 9 صفحه PDF سفارش دهید محاسبه نشده
خرید مقاله
پس از پرداخت، فوراً می توانید مقاله را دانلود فرمایید.
عنوان انگلیسی
Sleep supports cued fear extinction memory consolidation independent of circadian phase
منبع

Publisher : Elsevier - Science Direct (الزویر - ساینس دایرکت)

Journal : Neurobiology of Learning and Memory, Volume 132, July 2016, Pages 9–17

کلمات کلیدی
انقراض ترس ؛ تثبیت حافظه؛ فاز شبانه روزی؛ خواب؛ محرومیت از خواب
پیش نمایش مقاله
پیش نمایش مقاله خواب، تثبیت حافظه انقراض ترس نشانه دار مستقل از فاز تغییرات شبانه روزی را پشتیبانی می کند

چکیده انگلیسی

Sleep promotes memory, particularly for declarative learning. However, its role in non-declarative, emotional memories is less well understood. Some studies suggest that sleep may influence fear-related memories, and thus may be an important factor determining the outcome of treatments for emotional disorders such as post-traumatic stress disorder. Here, we investigated the effect of sleep deprivation and time of day on fear extinction memory consolidation. Mice were subjected to a cued Pavlovian fear and extinction paradigm at the beginning of their resting or active phase. Immediate post-extinction learning sleep deprivation for 5 h compromised extinction memory when tested 24 h after learning. Context-dependent extinction memory recall was completely prevented by sleep-manipulation during the resting phase, while impairment was milder during the active phase and extinction memory retained its context-specificity. Importantly, control experiments excluded confounding factors such as differences in baseline locomotion, fear generalization and stress hormone levels. Together, our findings indicate that post-learning sleep supports cued fear extinction memory consolidation in both circadian phases. The lack of correlation between memory efficacy and sleep time suggests that extinction memory may be influenced by specific sleep events in the early consolidation period.

خرید مقاله
پس از پرداخت، فوراً می توانید مقاله را دانلود فرمایید.