دانلود مقاله ISI انگلیسی شماره 71631
عنوان فارسی مقاله

ترانستیرتین: یک ژن کلیدی دخیل در نگهداری گنجایش حافظه در دوران پیری

کد مقاله سال انتشار مقاله انگلیسی ترجمه فارسی تعداد کلمات
71631 2008 12 صفحه PDF سفارش دهید محاسبه نشده
خرید مقاله
پس از پرداخت، فوراً می توانید مقاله را دانلود فرمایید.
عنوان انگلیسی
Transthyretin: A key gene involved in the maintenance of memory capacities during aging
منبع

Publisher : Elsevier - Science Direct (الزویر - ساینس دایرکت)

Journal : Neurobiology of Aging, Volume 29, Issue 11, November 2008, Pages 1721–1732

کلمات کلیدی
پیری - هیپوکامپ؛ بیان ژن؛ ترانستیرتین؛ رتینوئیک اسید؛ پیچ و خم آب موریس
پیش نمایش مقاله
پیش نمایش مقاله ترانستیرتین: یک ژن کلیدی دخیل در نگهداری گنجایش حافظه در دوران پیری

چکیده انگلیسی

Aging is often associated with decline of memory function. Aged animals, like humans, can naturally develop memory impairments and thus represent a useful model to investigate genes involved in long-term memory formation that are differentially expressed between aged memory-impaired (AI) and aged memory-unimpaired (AU) animals following stimulation in a spatial memory task. We found that alterations in hippocampal gene expression of transthyretin (TTR), calcineurin, and NAD(P)H dehydrogenase quinone 2 (NQO2) were associated with memory deficits in aged animals. Decreased TTR gene expression could be attributed at least partially to diminish activity of C/EBP immediate-early gene cascade initiated by CREB since protein levels of C/EBP, a transcription factor regulating both TTR and NQO2 expression, was decreased in AI animals. Memory deficits were also found during aging in mice lacking TTR, a retinol transporter known to prevent amyloid-β aggregation and plaque formation as seen in Alzheimer's disease. Treatment with retinoic acid reversed cognitive deficits in these knock-out mice as well as in aged rats. Our study provides genetic, behavioural and molecular evidence that TTR is involved in the maintenance of normal cognitive processes during aging by acting on the retinoid signalling pathway.

خرید مقاله
پس از پرداخت، فوراً می توانید مقاله را دانلود فرمایید.