دانلود مقاله ISI انگلیسی شماره 71856
عنوان فارسی مقاله

تغییرات پس از رفتار درمانی در بیماران پاسخگو و بدون پاسخ با اختلال وسواس اجباری

کد مقاله سال انتشار مقاله انگلیسی ترجمه فارسی تعداد کلمات
71856 2009 9 صفحه PDF سفارش دهید محاسبه نشده
خرید مقاله
پس از پرداخت، فوراً می توانید مقاله را دانلود فرمایید.
عنوان انگلیسی
Changes after behavior therapy among responsive and nonresponsive patients with obsessive-compulsive disorder
منبع

Publisher : Elsevier - Science Direct (الزویر - ساینس دایرکت)

Journal : Psychiatry Research: Neuroimaging, Volume 172, Issue 3, 30 June 2009, Pages 242–250

کلمات کلیدی
نقشه برداری پارامتری آماری؛ قشر جلوی مغز میانی؛ قشر فرونتال میانه
پیش نمایش مقاله
پیش نمایش مقاله تغییرات پس از رفتار درمانی در بیماران پاسخگو و بدون پاسخ با اختلال وسواس اجباری

چکیده انگلیسی

Neuroimaging studies have suggested that behavior therapy (BT) might change abnormal activity in the frontal-subcortical circuits of the brain in patients with obsessive-compulsive disorder (OCD). However, the results of these studies have been rather inconsistent. The aim of the present study was to use statistical parametric mapping (SPM) analysis to explore the effects of successful BT on regional cerebral blood flow (rCBF) in patients with OCD. Forty-five OCD patients who were treatment-resistant to a single serotonin reuptake inhibitor (SRI) trial were examined. Single photon emission computed tomography (SPECT) using 99mTc-ECD was performed before and after the completion of 12 weeks of BT. Although no significant differences in pre-treatment rCBF were observed between responders and nonresponders to BT, the post-treatment rCBF values in the left medial prefrontal cortex (Brodmann area 10) and bilateral middle frontal gyri (Brodmann area 10) were significantly lower in the responders than in the nonresponders. Furthermore, the baseline rCBF in the bilateral orbitofrontal cortex (OFC) was significantly correlated with the change in the Y-BOCS score among the responders. Our results support the hypothesis that while the OFC may be associated with the BT response, BT may result in changes in rCBF in the medial and middle frontal cortex.

خرید مقاله
پس از پرداخت، فوراً می توانید مقاله را دانلود فرمایید.