دانلود مقاله ISI انگلیسی شماره 71928
عنوان فارسی مقاله

ارتباطات عصبی حافظه شرح حال در اختلال خفیف شناختی زبان پریشى

کد مقاله سال انتشار مقاله انگلیسی ترجمه فارسی تعداد کلمات
71928 2012 9 صفحه PDF سفارش دهید محاسبه نشده
خرید مقاله
پس از پرداخت، فوراً می توانید مقاله را دانلود فرمایید.
عنوان انگلیسی
Neural correlates of autobiographical memory in amnestic Mild Cognitive Impairment
منبع

Publisher : Elsevier - Science Direct (الزویر - ساینس دایرکت)

Journal : Psychiatry Research: Neuroimaging, Volume 201, Issue 2, 28 February 2012, Pages 159–167

کلمات کلیدی
MRI عملکردی؛ مورفومتری مبتنی بر وکسل ؛ حافظه اپیزودیک؛ حافظه شرح حال
پیش نمایش مقاله
پیش نمایش مقاله ارتباطات عصبی حافظه شرح حال در اختلال خفیف شناختی زبان پریشى

چکیده انگلیسی

Episodic memory dysfunction, commonly assessed with word list recall, is the main characteristic of amnestic Mild Cognitive Impairment (aMCI). While brain pathology underlying this kind of memory impairment is well established in aMCI, little is known about the effect of neurodegeneration on autobiographical memory. The present study investigated neuronal correlates of autobiographical memory in aMCI patients (n = 12) and healthy elderly controls (n = 13) using functional magnetic resonance imaging (fMRI). Additionally, voxel-based morphometry (VBM) was employed to reveal brain pathology in aMCI patients. Neuropsychological assessment showed significant impairment in episodic memory tasks (immediate and delayed word list recall) in aMCI patients. Moreover, VBM revealed significantly reduced gray matter concentration, which was most pronounced in the temporal lobes of aMCI patients. Despite episodic memory impairment and atrophy in areas that are associated with encoding and recall of episodic memories, aMCI patients showed no alterations in brain activation associated with autobiographical memory retrieval. These findings could suggest that autobiographical memory is subserved by a different neuronal network than episodic memory and that the two memory systems are differently affected by aMCI.

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