دانلود مقاله ISI انگلیسی شماره 72072
عنوان فارسی مقاله

به سمت درک تفاوت های جنسی در درد احشایی: فعال سازی پیشرفته از ترس کلاسیک مطبوع در زنان سالم

کد مقاله سال انتشار مقاله انگلیسی ترجمه فارسی تعداد کلمات
72072 2014 9 صفحه PDF سفارش دهید محاسبه نشده
خرید مقاله
پس از پرداخت، فوراً می توانید مقاله را دانلود فرمایید.
عنوان انگلیسی
Towards understanding sex differences in visceral pain: Enhanced reactivation of classically-conditioned fear in healthy women
منبع

Publisher : Elsevier - Science Direct (الزویر - ساینس دایرکت)

Journal : Neurobiology of Learning and Memory, Volume 109, March 2014, Pages 113–121

کلمات کلیدی
حافظه هیجانی؛ تهویه ترس؛ تفاوت های جنسی؛ درد احشایی؛ تصویربرداری از مغز
پیش نمایش مقاله
پیش نمایش مقاله به سمت درک تفاوت های جنسی در درد احشایی: فعال سازی پیشرفته از ترس کلاسیک مطبوع در زنان سالم

چکیده انگلیسی

Sex differences in learned fear regarding aversive gastrointestinal stimuli could play a role in the female preponderance of chronic abdominal pain. In a fear conditioning model with rectal pain as unconditioned stimulus (US), we compared healthy males and females with respect to neural responses during aversive visceral learning, extinction and re-activation of fear memory (i.e., reinstatement). To do so, conditioned visual stimuli (CS+) were consistently paired with painful rectal distensions as US, while different visual stimuli (CS−) were presented without US. During extinction, both CSs were presented without US, whereas during reinstatement, a single, unpaired US was presented. In region-of-interest analyses, sexes were compared with respect to conditioned anticipatory neural activation (CS+ > CS−). The results revealed that in late acquisition, CS+ presentation induced significantly greater anticipatory activation of the insula in women. During extinction, women demonstrated reduced activation of the posterior cingulate cortex. During reinstatement, the CS+ led to greater activation of the hippocampus, thalamus and cerebellum in women. These group effects in neural activation during learning and memory processes were not accounted for by sex differences in pain thresholds, pain ratings, or stress parameters. In conclusion, this is the first study to support sex differences in neural processes mediating aversive visceral learning. Our finding of enhanced neural responses during reinstatement in key brain areas relevant for memory suggests enhanced reactivation of old fear memory trace in women. Sex differences in “gut memories” could play a role in the female preponderance of chronic abdominal pain.

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