دانلود مقاله ISI انگلیسی شماره 72102
عنوان فارسی مقاله

تفاوتهای جنسی در ارتباطات عصبی برانگیختگی اتونوم: یک مطالعه مقدماتی PET

کد مقاله سال انتشار مقاله انگلیسی ترجمه فارسی تعداد کلمات
72102 2011 10 صفحه PDF سفارش دهید 8981 کلمه
خرید مقاله
پس از پرداخت، فوراً می توانید مقاله را دانلود فرمایید.
عنوان انگلیسی
Sex differences in the neural correlates of autonomic arousal: A pilot PET study
منبع

Publisher : Elsevier - Science Direct (الزویر - ساینس دایرکت)

Journal : International Journal of Psychophysiology, Volume 80, Issue 3, June 2011, Pages 182–191

کلمات کلیدی
قشر قدامی مغز؛ هسته مرکزی آمیگدال؛ سیستم عصبی اتونوم؛تصویربرداری رزونانس مغناطیسی عملکردی؛
کلمات کلیدی انگلیسی
ACC, anterior cingulate cortex; ACe, central nucleus of the amygdala; ANS, autonomic nervous system; BLA, basolateral amygdala; BNST, bed nucleus of the stria terminalis; BOLD, blood oxygen level dependent (fMRI contrast mechanism); ECG, electrocardiograph; fMRI, functional magnetic resonance imaging; HR, Heart rate; HRV, heart rate variability; IBI, inter-beat interval; LBNP, Lower body negative pressure (autonomic challenge); lnHF, Natural log of high frequency power of the heart rate spectrum. An indicator of parasympathetic activation; lnLF, Natural log of low frequency power of the heart rate spectrum. Partially dependent on sympathetic tone, but strongly dependent on parasympathetic activity as well; LF/HF, Ratio of low to high frequency power, generally used as an index of the balance of sympathetic to parasympathetic tone; OFC, orbitofrontal cortex; PCC, posterior cingulate cortex; PET, positron emission tomography; PFC, prefrontal cortex; rCBF, regional cerebral blood flow; RMSSD, Root mean square standard deviation of successive R-R intervals of the heart rate time series. An index of parasympathetic tone; ROI, region of interest; STG, superior temporal cortexAutonomic; HRV; PET; Sex; Amygdala
پیش نمایش مقاله
پیش نمایش مقاله تفاوتهای جنسی در ارتباطات عصبی برانگیختگی اتونوم: یک مطالعه مقدماتی PET

چکیده انگلیسی

Electrophysiology, behavioral, and neuroimaging studies have revealed sex-related differences in autonomic cardiac control, as reflected in measurements of heart rate variability (HRV). Imaging studies indicate that the neurobiological correlates of autonomic nervous system (ANS) function can be investigated by measuring indices of HRV during the performance of mildly strenuous motor tasks or mildly stressful cognitive tasks. In this preliminary study, fifteen male and seven female healthy subjects underwent H215O-positron emission tomography (PET) and electrocardiograph (ECG) recording while performing a handgrip motor task and an n-back task. Indices of HRV were calculated and correlated with regional cerebral blood flow (rCBF). We hypothesized that sex differences would be evident in brain regions known to participate in autonomic regulation: the anterior insula, the anterior cingulate cortex, the orbitofrontal cortex, and the amygdala. Our study found that associations between rCBF and parasympathetic indices differed significantly between female and male subjects in the amygdala. Females showed a positive correlation between rCBF and parasympathetic indices while males exhibited negative correlations. This differential correlation of amygdala rCBF and parasympathetic activity between males and females may reflect differences in parasympathetic/sympathetic balance between sexes, consistent with known sexual dimorphism in the amygdala and closely related structures such as the hypothalamus. These preliminary imaging results are consistent with earlier reports of significant correlation between brain activity and HRV, and extend these findings by demonstrating prominent sex differences in the neural control of the ANS. While the generalizability of our results was limited by the small size of the study samples, the relatively robust effect size of the differences found between groups encourages further work in larger samples to characterize sex differences in the neural correlates of autonomic arousal.

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