دانلود مقاله ISI انگلیسی شماره 72186
عنوان فارسی مقاله

اثرات ضداضطرابی حاد کواتیاپین در طول مواجهه واقعیت مجازی؛ یک آزمایش کنترل شده با پلاسبو دو سو کور در بیماران مبتلا به هراس خاص

کد مقاله سال انتشار مقاله انگلیسی ترجمه فارسی تعداد کلمات
72186 2013 10 صفحه PDF سفارش دهید محاسبه نشده
خرید مقاله
پس از پرداخت، فوراً می توانید مقاله را دانلود فرمایید.
عنوان انگلیسی
Acute anxiolytic effects of quetiapine during virtual reality exposure—A double-blind placebo-controlled trial in patients with specific phobia
منبع

Publisher : Elsevier - Science Direct (الزویر - ساینس دایرکت)

Journal : European Neuropsychopharmacology, Volume 23, Issue 11, November 2013, Pages 1551–1560

کلمات کلیدی
کواتیاپین؛ اختلالات اضطرابی؛ چالش؛ واقعیت مجازی؛ روانی فیزیولوژی ؛ COMT
پیش نمایش مقاله
پیش نمایش مقاله اثرات ضداضطرابی حاد کواتیاپین در طول مواجهه واقعیت مجازی؛ یک آزمایش کنترل شده با پلاسبو دو سو کور در بیماران مبتلا به هراس خاص

چکیده انگلیسی

Anxiety disorders are among the most frequent psychiatric disorders. With regard to pharmacological treatment, antidepressants, the calcium modulator pregabalin and benzodiazepines are recommended according to current treatment guidelines. With regard to acute states of anxiety, so far practically only benzodiazepines provide an immediate anxiolytic effect. However, the risk of tolerance and dependency limits the use of this class of medication. Therefore, there is still a need for alternative pharmacologic strategies. Increasing evidence points towards anxiety-reducing properties of atypical antipsychotics, particularly quetiapine. Therefore, we aimed to evaluate the putative acute anxiolytic effects of this compound, choosing the induction of acute anxiety in patients with specific phobia as a model for the evaluation of ad-hoc anxiolytic properties in a proof-of-concept approach. In a randomized, double-blind, placebo-controlled study, 58 patients with arachnophobia were treated with a single dose of quetiapine XR or placebo prior to a virtual reality spider challenge procedure. Treatment effects were monitored using rating scales for acute anxiety as well as measurements of heart rate and skin conductance. Overall, quetiapine showed significant anxiolytic effects compared to placebo. However, effects were not seen on the primary outcome measure (VAS Anxiety), but were limited to somatic anxiety symptoms. Additionally, a significant reduction of skin conductance was observed. Further exploratory analyses hint towards a mediating role of the (COMT) val158met genotype on treatment response. The present results thus suggest a possible suitability of quetiapine in the acute treatment of anxiety, particularly with regard to somatic symptoms.

خرید مقاله
پس از پرداخت، فوراً می توانید مقاله را دانلود فرمایید.