دانلود مقاله ISI انگلیسی شماره 72239
عنوان فارسی مقاله

ایمی پرامین کمکی برای گروه گسترده تری از افسردگی پس از روان پریشی در اسکیزوفرنی

کد مقاله سال انتشار مقاله انگلیسی ترجمه فارسی تعداد کلمات
72239 2000 6 صفحه PDF سفارش دهید محاسبه نشده
خرید مقاله
پس از پرداخت، فوراً می توانید مقاله را دانلود فرمایید.
عنوان انگلیسی
Adjunctive imipramine for a broader group of post-psychotic depressions in schizophrenia ☆
منبع

Publisher : Elsevier - Science Direct (الزویر - ساینس دایرکت)

Journal : Schizophrenia Research, Volume 44, Issue 3, 1 September 2000, Pages 187–192

کلمات کلیدی
استراتژی دارو کمکی - داروهای ضد افسردگی؛ دارو نورولپتیک؛ افسردگی پس از روانی؛ جنون جوانی
پیش نمایش مقاله
پیش نمایش مقاله ایمی پرامین کمکی برای گروه گسترده تری از افسردگی پس از روان پریشی در اسکیزوفرنی

چکیده انگلیسی

As an expansion of work examining the usefulness of adjunctive imipramine added to fluphenazine decanoate and benztropine in the treatment of post-psychotic depression, a previously successful and informative protocol was extended to a larger and more heterogeneous cohort of clinic and day-treatment patients. Although the benefit of the adjunctive antidepressant strategy was still observable in the total sample, as calculated by the prospectively intended data analysis, the findings were weaker than those obtained for the initial cohort. Owing to the possibility that differences between the later and earlier cohorts might account for the muted nature of the benefit, a post-hoc analysis was undertaken. This revealed that the later cohort was sicker in general and more psychotic in particular. The later cohort was also treated with lower doses of neuroleptic medication while remaining out of hospital longer, consistent with more recent treatment trends. It was also possible that the later cohort was subtly selected for more refractoriness of depression, since treatment of post-psychotic depression with adjunctive antidepressants had become more commonplace, and patients responding to this in general practice would not have gone on to be referred to the study. Thus a benefit from adjunctive antidepressant medication persists, but more remains to be learned about its character and likelihood in specific situations.

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