دانلود مقاله ISI انگلیسی شماره 72241
عنوان فارسی مقاله

تغییرات غددی عصبی طولی ارزیابی شده توسط دگزامتازون / CRH و هورمون رشد با انتشار آزمایشات هورمونی در افسردگی سایکوتیک

کد مقاله سال انتشار مقاله انگلیسی ترجمه فارسی تعداد کلمات
72241 2008 10 صفحه PDF سفارش دهید محاسبه نشده
خرید مقاله
پس از پرداخت، فوراً می توانید مقاله را دانلود فرمایید.
عنوان انگلیسی
Longitudinal neuroendocrine changes assessed by dexamethasone/CRH and growth hormone releasing hormone tests in psychotic depression
منبع

Publisher : Elsevier - Science Direct (الزویر - ساینس دایرکت)

Journal : Psychoneuroendocrinology, Volume 33, Issue 2, February 2008, Pages 152–161

کلمات کلیدی
هورمون آزاد کننده کورتیکوتروپین ؛دگزامتازون ؛افسردگی سایکوتیک
پیش نمایش مقاله
پیش نمایش مقاله تغییرات غددی عصبی طولی ارزیابی شده توسط دگزامتازون / CRH و هورمون رشد با انتشار آزمایشات هورمونی در افسردگی سایکوتیک

چکیده انگلیسی

Although psychotic depression has been reported to exhibit a greater degree of dysregulation of hypothalamic–pituitary–adrenocortical (HPA) function than non-psychotic depression, little is known concerning hypothalamic–pituitary–somatotropic (HPS) function in psychotic depression and how neuroendocrine function changes after treatment. To investigate the longitudinal changes in HPA and HPS system function in psychotic depression, we performed repeated dexamethasone/corticotropin releasing hormone (DEX/CRH) tests and growth hormone (GH) releasing hormone (GHRH) tests in inpatients with major depressive disorder. The psychotic depression group exhibited greater elevation of ACTH responses to the DEX/CRH test and stronger decreases in GH responses to the GHRH test than the non-psychotic depression group at admission. At discharge, the neuroendocrine responses to the DEX/CRH test of the psychotic depression group were still stronger than those of the non-psychotic depression group, though there were no significant differences in severity of depression between the groups. There were significant longitudinal changes in neuroendocrine responses to the DEX/CRH test between admission and discharge. The psychotic depression group exhibited increased GH responses to GHRH at discharge compared with those at admission, whereas no significant longitudinal change in GH response was found in the non-psychotic depression group. Consequently, there were no significant differences in GH responses to GHRH between the psychotic and non-psychotic depression groups at discharge. The results of GHRH test showed no significant relationships with severity of depression except psychotic features and the results of the DEX/CRH test. Our findings suggest that the HPS axis may be associated with psychotic features rather than general severity of depression. Further longitudinal studies are needed to clarify the role of HPS function in psychotic depression and whether sustained dysregulation of HPA function in psychotic depression is associated with a poor outcome after discharge.

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پس از پرداخت، فوراً می توانید مقاله را دانلود فرمایید.