دانلود مقاله ISI انگلیسی شماره 72422
عنوان فارسی مقاله

ارتباط بین عملکرد شناختی، قرار گرفتن در معرض ویروس هرپس سیمپلکس نوع 1 و پلی مورفیسم ژنتیکی COMT Val158Met در بزرگسالان بدون یک اختلال روانی

کد مقاله سال انتشار مقاله انگلیسی ترجمه فارسی تعداد کلمات
72422 2008 5 صفحه PDF سفارش دهید محاسبه نشده
خرید مقاله
پس از پرداخت، فوراً می توانید مقاله را دانلود فرمایید.
عنوان انگلیسی
Association between cognitive functioning, exposure to Herpes Simplex Virus type 1, and the COMT Val158Met genetic polymorphism in adults without a psychiatric disorder
منبع

Publisher : Elsevier - Science Direct (الزویر - ساینس دایرکت)

Journal : Brain, Behavior, and Immunity, Volume 22, Issue 7, October 2008, Pages 1103–1107

کلمات کلیدی
عفونت هرپس؛ ویروس هرپس سیمپلکس نوع 1؛ شناخت؛ حافظه؛ پلی مورفیسم COMT Val158Met
پیش نمایش مقاله
پیش نمایش مقاله ارتباط بین عملکرد شناختی، قرار گرفتن در معرض ویروس هرپس سیمپلکس نوع 1 و پلی مورفیسم ژنتیکی COMT Val158Met در بزرگسالان بدون یک اختلال روانی

چکیده انگلیسی

Previous studies have documented that serologic evidence of infection with the neurotropic human herpesvirus Herpes Simplex Virus type 1 (HSV-1) is associated with increased levels of cognitive dysfunction in individuals with schizophrenia or bipolar disorder. The catechol-o-methyl transferase (COMT) Val158Met polymorphism has also been associated with cognitive dysfunction in individuals with psychiatric disorders as well as in some control populations. We examined whether these factors are independently associated with cognitive functioning in adults without a history of a psychiatric disorder. A total of 240 individuals were evaluated with the Repeatable Battery for the Assessment of Neuropsychological Status (RBANS) and the Wisconsin Card Sorting Test (WCST). We measured IgG antibodies to HSV-1 by enzyme immunoassay and employed real time PCR to measure COMT Val158Met genotypes. Serological evidence of HSV-1 was significantly associated with a lower RBANS total score independent of demographic factors and the COMT Val158Met genotype. The strongest association between cognitive functioning and serological evidence of HSV-1 infection was with the domain of delayed memory. Serological evidence of HSV-1 infection was associated with an 18-fold increased odds of having a severe impairment in this domain. The Val/Val genotype of the COMT Val158Met polymorphism was also significantly associated with the RBANS total score and with a moderate decrease in the domain of attention. Infections with HSV-1 and the COMT Val158Val genotype are risk factors for cognitive deficits in non-elderly persons without a psychiatric disorder.

خرید مقاله
پس از پرداخت، فوراً می توانید مقاله را دانلود فرمایید.