دانلود مقاله ISI انگلیسی شماره 72501
عنوان فارسی مقاله

آسیب سد خونی مغزی به عنوان یک عامل خطر برای اختلالات روانپزشکی القاء شده با کورتیکواستروئید در لوپوس اریتماتوی سیستمیک

کد مقاله سال انتشار مقاله انگلیسی ترجمه فارسی تعداد کلمات
72501 2008 9 صفحه PDF سفارش دهید محاسبه نشده
خرید مقاله
پس از پرداخت، فوراً می توانید مقاله را دانلود فرمایید.
عنوان انگلیسی
Blood-brain barrier damage as a risk factor for corticosteroid-induced psychiatric disorders in systemic lupus erythematosus
منبع

Publisher : Elsevier - Science Direct (الزویر - ساینس دایرکت)

Journal : Psychoneuroendocrinology, Volume 33, Issue 3, April 2008, Pages 395–403

کلمات کلیدی
اختلالات روانپزشکی القاء شده با کورتیکواستروئید؛ لوپوس اریتماتوی سیستمیک؛ سد خونی مغزی؛ آلبومین؛ مکمل؛ لوپوس سیستم عصبی مرکزی
پیش نمایش مقاله
پیش نمایش مقاله آسیب سد خونی مغزی به عنوان یک عامل خطر برای اختلالات روانپزشکی القاء شده با کورتیکواستروئید در لوپوس اریتماتوی سیستمیک

چکیده انگلیسی

To clarify the incidence of and risk factors for corticosteroid-induced psychiatric disorders (CIPDs) in patients with systemic lupus erythematosus (SLE), we conducted a prospective study of 161 consecutive episodes in 155 inpatients with a SLE flare who were treated with corticosteroids. A subgroup of these patients, those who experienced a total of 22 episodes with current overt central nervous system manifestations of SLE (CNS-SLE), were excluded from follow-up. Results of clinical, laboratory, and neurologic tests (including electroencephalography, magnetic resonance imaging of the brain, and cerebrospinal fluid [CSF] analysis), performed within a week before corticosteroid administration, were assessed with regard to development of CIPDs. Within 8 weeks of corticosteroid administration, a diagnosis of CIPD was made for 14 (10.1%) of 139 episodes in 135 patients with a non-CNS-SLE flare. Using multiple logistic regression analysis, we identified positive Qalbumin (CSF/serum albumin ratio; an indicator of blood-brain barrier [BBB] damage) (odds ratio [OR], 33.3; 95% confidence interval [CI], 3.64–304; p=0.002) and low serum levels of complements (OR, 0.91; 95% CI, 0.83–1.00; p=0.047) as independent risk factors for CIPDs. Positive Qalbumin was detected in 45% (5 of 11) of episodes in which CIPDs developed. Compared with episodes in which no psychiatric events occurred, a higher level of Qalbumin was found in episodes in which CIPDs developed, and an even higher level was noted in episodes with active CNS-SLE (Jonckheere-Terpstra test, p<0.001). Although no causal links have been proven, the results from the present study raise the possibility that BBB damage may be associated with SLE- and corticosteroid-induced behavioral changes.

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