دانلود مقاله ISI انگلیسی شماره 72561
عنوان فارسی مقاله

ماست سل های دگرانولاسیون شده در پوست بزرگسالان با رفتارهای خودآزاری و اختلالات عصبی تکاملی

کد مقاله سال انتشار مقاله انگلیسی ترجمه فارسی تعداد کلمات
72561 2009 6 صفحه PDF سفارش دهید محاسبه نشده
خرید مقاله
پس از پرداخت، فوراً می توانید مقاله را دانلود فرمایید.
عنوان انگلیسی
Degranulated mast cells in the skin of adults with self-injurious behavior and neurodevelopmental disorders
منبع

Publisher : Elsevier - Science Direct (الزویر - ساینس دایرکت)

Journal : Brain, Behavior, and Immunity, Volume 23, Issue 3, March 2009, Pages 365–370

کلمات کلیدی
خودآزاری؛ ناتوانی ذهنی؛ عصب محیطی
پیش نمایش مقاله
پیش نمایش مقاله ماست سل های دگرانولاسیون شده در پوست بزرگسالان با رفتارهای خودآزاری و اختلالات عصبی تکاملی

چکیده انگلیسی

The role of nociceptive processes in relation to chronic, tissue-damaging self-injury among individuals with neurodevelopmental disorders is poorly understood. Scientific investigation has been limited, in part, by the clinical reality that the majority of individuals with severe intellectual impairments have co-morbid communicative impairments making it difficult to ascertain information regarding pain. Recently, we found abnormal patterns of peripheral epidermal nerve fiber (ENF) innervation and increased neuropeptide (substance P; SP) content among a subset of individuals with chronic self-injury. Here, we provide initial evidence for peripheral neuro-immune activity specific to self-injury. Skin samples from non-injury body-matched sites were compared between non-verbal adults with and without self-injury matched on gender and disability level. Relative to disability-matched controls, individuals with chronic self-injury had significantly more degranulated mast cells and were more responsive to tactile stimulation during a sensory testing procedure. Thus, nociceptive mechanisms and peripheral afferent sensitization may play a part in mediating and maintaining chronic self-injury.

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پس از پرداخت، فوراً می توانید مقاله را دانلود فرمایید.