دانلود مقاله ISI انگلیسی شماره 72575
عنوان فارسی مقاله

تغییر هیپوتالاموس هیپوفیز آدرنال عملکرد در میمونهای رزوس با رفتارهای خودآزاری

کد مقاله سال انتشار مقاله انگلیسی ترجمه فارسی تعداد کلمات
72575 2004 15 صفحه PDF سفارش دهید محاسبه نشده
خرید مقاله
پس از پرداخت، فوراً می توانید مقاله را دانلود فرمایید.
عنوان انگلیسی
Altered hypothalamic–pituitary–adrenocortical function in rhesus monkeys (Macaca mulatta) with self-injurious behavior
منبع

Publisher : Elsevier - Science Direct (الزویر - ساینس دایرکت)

Journal : Psychoneuroendocrinology, Volume 29, Issue 4, May 2004, Pages 501–515

کلمات کلیدی
رفتار خودآزارانه ؛ خود نیش زنی ؛ کورتیزول؛ چالش دگزامتازون؛ چالش ACTH؛ میمون رزوس
پیش نمایش مقاله
پیش نمایش مقاله تغییر هیپوتالاموس هیپوفیز آدرنال عملکرد در میمونهای رزوس با رفتارهای خودآزاری

چکیده انگلیسی

Individually housed rhesus monkeys sometimes spontaneously develop self-injurious behavior (SIB) in the form of self-directed biting that, on occasion, results in severe tissue damage and mutilation. We previously demonstrated lower levels of plasma cortisol in rhesus monkeys with a history of self-wounding (SW) when compared to non-wounders (NW). Furthermore, cortisol levels were negatively correlated with rates of self-directed biting. The present study was designed to further characterize the relationships between hypothalamic–pituitary–adrenocortical (HPA) activity, self-wounding, and self-directed biting. Basal 24-h urinary free cortisol excretion, the urinary free cortisol response to a low dose of dexamethasone, and the plasma cortisol response to ACTH were examined in 24 individually housed rhesus monkeys, based on wounding history, i.e. the presence/absence of a veterinary record of self-wounding, and current rates of self-directed biting, i.e. the median split of self-directed biting frequency (independent of wounding status). There were no reliable group differences on any of the physiological measures when analyzed by wounding history. However, the plasma cortisol response 30 min post-ACTH stimulation was significantly correlated with wounding recency, such that lower responsivity was associated with more recent wounding episodes. When the results were analyzed on the basis of biting frequency, high frequency biters (HFB) compared to low frequency biters (LFB) showed decreased HPA negative feedback sensitivity to dexamethasone and a trend towards an attenuated plasma cortisol response to ACTH stimulation. These findings suggest that SIB in socially reared monkeys is associated with complex changes in HPA axis function that are related to the expression of the pathology, i.e. self-directed biting, and to the recency of a wounding episode. It remains to be determined whether humans who exhibit SIB show similar alterations in HPA function.

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پس از پرداخت، فوراً می توانید مقاله را دانلود فرمایید.