دانلود مقاله ISI انگلیسی شماره 72616
عنوان فارسی مقاله

پیوند سلول های کرومافین انسانی به CSF برای مدیریت درد سرطان: یک مرحله آینده نگر مطالعه بالینی دوم

کد مقاله سال انتشار مقاله انگلیسی ترجمه فارسی تعداد کلمات
72616 2000 14 صفحه PDF سفارش دهید محاسبه نشده
خرید مقاله
پس از پرداخت، فوراً می توانید مقاله را دانلود فرمایید.
عنوان انگلیسی
Human chromaffin cell graft into the CSF for cancer pain management: a prospective phase II clinical study
منبع

Publisher : Elsevier - Science Direct (الزویر - ساینس دایرکت)

Journal : Pain, Volume 87, Issue 1, 1 July 2000, Pages 19–32

کلمات کلیدی
درد سرطان؛ سلول های کرومافین؛ آلوگرافت؛ مورفین اینتراتکال؛ ملاقات انکفالین
پیش نمایش مقاله
پیش نمایش مقاله پیوند سلول های کرومافین انسانی به CSF برای مدیریت درد سرطان: یک مرحله آینده نگر مطالعه بالینی دوم

چکیده انگلیسی

A number of pre-clinical studies have demonstrated the value of adrenal medullary allografts in the management of chronic pain. The present longitudinal survey studied 15 patients transplanted for intractable cancer pain after failure of systemic opioids due to the persistence of undesirable side-effects. Before inclusion, all the patients had their pain controlled by daily intrathecal (I-Th) morphine administration. The main evaluation criteria of analgesic activity of the chromaffin cell allograft was the complementary requirement of analgesics and in particular the consumption of I-Th morphine required to maintain effective pain control. Out of the 12 patients who profited from enhanced analgesia with long-term follow-up (average 4.5 months), five no longer required the I-Th morphine (with prolonged interruption of systemic opioids as well), two durably decreased I-Th morphine intake and five were stabilized until the end of their follow-up. Durable decline and stabilization were interpreted as indicative of analgesic activity by comparison with the usual dose escalation observed during disease progression. In most cases, we noted a relationship between analgesic responses and CSF met-enkephalin levels. The results of this phase II open study demonstrate the feasibility and the safety of this approach using chromaffin cell grafts for long-term relief of intractable cancer pain. However, while analgesic efficacy was indicated by the reduction or stabilization in complementary opioid intake, these observations will need to be confirmed in a controlled trial in a larger series of patients.

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