دانلود مقاله ISI انگلیسی شماره 72729
عنوان فارسی مقاله

فقدان لذت و افسردگی اساسی: نقش آگوملاتین

کد مقاله سال انتشار مقاله انگلیسی ترجمه فارسی تعداد کلمات
72729 2012 6 صفحه PDF سفارش دهید محاسبه نشده
خرید مقاله
پس از پرداخت، فوراً می توانید مقاله را دانلود فرمایید.
عنوان انگلیسی
Anhedonia and major depression: The role of agomelatine
منبع

Publisher : Elsevier - Science Direct (الزویر - ساینس دایرکت)

Journal : European Neuropsychopharmacology, Volume 22, Supplement 3, 2012, Pages S505–S510

کلمات کلیدی
افسردگی؛ لذت؛ شکل ها
پیش نمایش مقاله
پیش نمایش مقاله فقدان لذت و افسردگی اساسی: نقش آگوملاتین

چکیده انگلیسی

Anhedonia is a condition in which the capacity to experience pleasure is totally or partially lost. Although anhedonia is a feature of major depressive disorder according to DSM IV criteria for major depression diagnosis, so far it has received relatively little attention. The scale that is most commonly used in the measurement of anhedonia is the Snaith-Hamilton Pleasure Scale (SHAPS), a brief 14-item self-report questionnaire designed to measure hedonic tone and its absence. Two studies have described the efficacy of agomelatine in the treatment of anhedonia: an open-label study and a comparative trial versus the antidepressant venlafaxine XR. In both studies agomelatine significantly reduced anhedonia, as indicated using the SHAPS. This reduction was observed after the first week of treatment (P<0.05) and at different times until the end of the trial. Moreover, in the comparative trial, a significant difference between groups was observed in favor of agomelatine, after 1 (P<0.05), 2 (P<0.01), and 8 weeks (P<0.01). The possible effect of agomelatine on anhedonia may represent a novel area of interest among antidepressant agents and deserves further investigation, with larger samples and double-blind placebo-controlled designs.

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