دانلود مقاله ISI انگلیسی شماره 72751
عنوان فارسی مقاله

اثر تجویز کورتیزول حاد بر مهار پاسخ در بیماران مبتلا به افسردگی اساسی و افراد سالم

کد مقاله سال انتشار مقاله انگلیسی ترجمه فارسی تعداد کلمات
72751 2013 8 صفحه PDF سفارش دهید محاسبه نشده
خرید مقاله
پس از پرداخت، فوراً می توانید مقاله را دانلود فرمایید.
عنوان انگلیسی
Effects of acute cortisol administration on response inhibition in patients with major depression and healthy controls
منبع

Publisher : Elsevier - Science Direct (الزویر - ساینس دایرکت)

Journal : Psychiatry Research, Volume 209, Issue 3, 30 October 2013, Pages 439–446

کلمات کلیدی
اختلال افسردگی اساسی - محور هیپوتالاموس ؛ قشر جلوی مغز؛ انسان
پیش نمایش مقاله
پیش نمایش مقاله اثر تجویز کورتیزول حاد بر مهار پاسخ در بیماران مبتلا به افسردگی اساسی و افراد سالم

چکیده انگلیسی

Glucocorticoids (GCs) have repeatedly been shown to impair hippocampus-mediated, declarative memory retrieval and prefrontal cortex-based working memory in healthy subjects. However, recent experimental studies indicated that patients with major depressive disorder (MDD) lack these impairing effects. These missing effects have been suggested to result from dysfunctional brain GC receptors. The purpose of the present study was to investigate whether response inhibition, an executive function relying on the integrity of the prefrontal cortex, would be impaired after cortisol administration in patients with MDD. In a placebo-controlled, double blind crossover study, 50 inpatients with MDD and 54 healthy control participants conducted an emotional go/no-go task consisting of human face stimuli (fearful, happy, and neutral) after receiving a dose of 10 mg hydrocortisone and after placebo. GC administration had an enhancing effect on inhibitory performance in healthy control participants, indicated by faster responses, while no GC effect was revealed for the patients group. Moreover, patients showed an overall worse performance than healthy participants. In conclusion, this study further supports the hypothesis of impaired central glucocorticoid receptor function in MDD patients. Regarding the importance of inhibitory functioning for daily living, further studies are needed to examine the impact of glucocorticoids on response inhibition.

خرید مقاله
پس از پرداخت، فوراً می توانید مقاله را دانلود فرمایید.