دانلود مقاله ISI انگلیسی شماره 72765
عنوان فارسی مقاله

تاثیر گرلین بر آسیب شناسی روانی، خواب و ترشح کورتیزول و هورمون رشد در بیماران مبتلا به افسردگی اساسی

کد مقاله سال انتشار مقاله انگلیسی ترجمه فارسی تعداد کلمات
72765 2011 6 صفحه PDF سفارش دهید محاسبه نشده
خرید مقاله
پس از پرداخت، فوراً می توانید مقاله را دانلود فرمایید.
عنوان انگلیسی
Effects of ghrelin on psychopathology, sleep and secretion of cortisol and growth hormone in patients with major depression
منبع

Publisher : Elsevier - Science Direct (الزویر - ساینس دایرکت)

Journal : Journal of Psychiatric Research, Volume 45, Issue 3, March 2011, Pages 421–426

کلمات کلیدی
گرلین؛ افسردگی شدید؛ شدت علائم؛ کورتیزول؛ هورمون رشد؛ خواب
پیش نمایش مقاله
پیش نمایش مقاله تاثیر گرلین بر آسیب شناسی روانی، خواب و ترشح کورتیزول و هورمون رشد در بیماران مبتلا به افسردگی اساسی

چکیده انگلیسی

Ghrelin showed antidepressant-like effects in mice. Furthermore, ghrelin influences sleep and the activity of hypothalamic-pituitary-adrenal (HPA) and somatotropic axis in healthy humans as indicated by increased cortisol and growth hormone (GH) plasma levels. Both sleep and the activity of these endocrine axes are disturbed in depression. We therefore studied the impact of ghrelin on psychopathology, sleep and secretion of cortisol and GH in patients with major depression. Depressive symptoms as assessed by a validated self rating scale (‘Befindlichkeits-Skala’, [mental state scale]), secretion profiles of cortisol and GH and sleep-EEGs were determined in 14 unmedicated patients with major depression (7 women) twice, receiving 50 μg ghrelin or placebo at 22:00, 23:00, 00:00, and 01:00 hours. Overall, depressive symptoms did not change significantly after ghrelin administration (placebo: 37 ± 8; ghrelin: 33 ± 10, p = 0.178). However, there was an improvement at trend level in men (placebo: 36 ± 9 to ghrelin: 30 ± 9, p = 0.093) but not in women. In men, ghrelin was associated with less time awake (placebo: 149.0 ± 11.1; ghrelin: 88.0 ± 12.2 min, p = 0.029) and more non-REM sleep (placebo: 263.2 ± 24.1; ghrelin: 304.9 ± 14.1 min, p = 0.027), in women with less REM sleep (placebo: 108.6 ± 15.7; ghrelin: 74.1 ± 13.8 min, p = 0.031) and longer REM latency (placebo: 49.9 ± 6.5; ghrelin: 85.6 ± 14.1 min, p = 0.019). In both sexes, ghrelin caused strong transient increases of GH and cortisol. In conclusion, our study may provide some initial indication that ghrelin can exert antidepressant effects in patients with major depression. Ghrelin strongly affected sleep and secretion of GH and cortisol in a partly different way as previously reported in healthy subjects.

خرید مقاله
پس از پرداخت، فوراً می توانید مقاله را دانلود فرمایید.