دانلود مقاله ISI انگلیسی شماره 72830
عنوان فارسی مقاله

تفاوت ضخامت ماده خاکستری منطقه قشر مغز مرتبط با دیابت نوع 2 و اختلال افسردگی اساسی

کد مقاله سال انتشار مقاله انگلیسی ترجمه فارسی تعداد کلمات
72830 2010 8 صفحه PDF سفارش دهید محاسبه نشده
خرید مقاله
پس از پرداخت، فوراً می توانید مقاله را دانلود فرمایید.
عنوان انگلیسی
Regional cortical gray matter thickness differences associated with type 2 diabetes and major depression ☆
منبع

Publisher : Elsevier - Science Direct (الزویر - ساینس دایرکت)

Journal : Psychiatry Research: Neuroimaging, Volume 184, Issue 2, 30 November 2010, Pages 63–70

کلمات کلیدی
کالبدشناسی اعصاب؛ حالت؛ دیابت
پیش نمایش مقاله
پیش نمایش مقاله تفاوت ضخامت ماده خاکستری منطقه قشر مغز مرتبط با دیابت نوع 2 و اختلال افسردگی اساسی

چکیده انگلیسی

The purpose of this study was to examine the effect of type 2 diabetes with major depression on cortical gray matter using magnetic resonance imaging and cortical pattern matching techniques. We hypothesized that diabetic subjects and depressed diabetic subjects would demonstrate decreased cortical gray matter thickness in prefrontal areas as compared to healthy control subjects. Patients with type 2 diabetes (n = 26) and patients with diabetes and major depression (n = 26) were compared with healthy controls (n = 20). Gray matter thickness across the entire cortex was measured using cortical pattern matching methods. All subjects with diabetes demonstrated decreased cortical gray matter thickness in the left anterior cingulate region. Additionally, depressed diabetic subjects showed significant cortical gray matter decreases in bilateral prefrontal areas compared with healthy controls. Correlations between clinical variables and cortical gray matter thickness revealed a significant negative relationship with cerebrovascular risk factors across all three groups, most consistently in the left dorsomedial prefrontal cortex. A significant positive relationship between performance on attention and executive function tasks and cortical gray matter thickness predominately in left hemisphere regions was also seen across all subjects. Depression and diabetes are associated with significant cortical gray matter thinning in medial prefrontal areas.

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