دانلود مقاله ISI انگلیسی شماره 72849
عنوان فارسی مقاله

فقدان لذت خصلتی با کاهش فعالیت و اتصال گذرگاه پاداش مزولیمبیک و پارالیمیک در ارتباط است

کد مقاله سال انتشار مقاله انگلیسی ترجمه فارسی تعداد کلمات
72849 2013 10 صفحه PDF سفارش دهید محاسبه نشده
خرید مقاله
پس از پرداخت، فوراً می توانید مقاله را دانلود فرمایید.
عنوان انگلیسی
Trait anhedonia is associated with reduced reactivity and connectivity of mesolimbic and paralimbic reward pathways
منبع

Publisher : Elsevier - Science Direct (الزویر - ساینس دایرکت)

Journal : Journal of Psychiatric Research, Volume 47, Issue 10, October 2013, Pages 1319–1328

کلمات کلیدی
فقدان لذت؛ سیستم پاداش مزولیمبیک ؛ نوکلئوس اکومبنس؛ عایق؛ منطقه تگمنتوم شکمی
پیش نمایش مقاله
پیش نمایش مقاله فقدان لذت خصلتی با کاهش فعالیت و اتصال گذرگاه پاداش مزولیمبیک و پارالیمیک در ارتباط است

چکیده انگلیسی

Anhedonia is the inability to experience pleasure from normally pleasant stimuli. Although anhedonia is a prominent feature of many psychiatric disorders, trait anhedonia is also observed dimensionally in healthy individuals. Currently, the neurobiological basis of anhedonia is poorly understood because it has been mainly investigated in patients with psychiatric disorders. Thus, previous studies have not been able to adequately disentangle the neural correlates of anhedonia from other clinical symptoms. In this study, trait anhedonia was assessed in well-characterized healthy participants with no history of Axis I psychiatric illness. Functional magnetic resonance imaging with musical stimuli was used to examine brain responses and effective connectivity in relation to individual differences in anhedonia. We found that trait anhedonia was negatively correlated with pleasantness ratings of music stimuli and with activation of key brain structures involved in reward processing, including nucleus accumbens (NAc), basal forebrain and hypothalamus which are linked by the medial forebrain bundle to the ventral tegmental area (VTA). Brain regions important for processing salient emotional stimuli, including anterior insula and orbitofrontal cortex were also negatively correlated with trait anhedonia. Furthermore, effective connectivity between NAc, VTA and paralimbic areas, that regulate emotional reactivity to hedonic stimuli, was negatively correlated with trait anhedonia. Our results indicate that trait anhedonia is associated with reduced reactivity and connectivity of mesolimbic and related limbic and paralimbic systems involved in reward processing. Critically, this association can be detected even in individuals without psychiatric illness. Our findings have important implications both for understanding the neurobiological basis of anhedonia and for the treatment of anhedonia in psychiatric disorders.

خرید مقاله
پس از پرداخت، فوراً می توانید مقاله را دانلود فرمایید.