دانلود مقاله ISI انگلیسی شماره 72883
عنوان فارسی مقاله

خصلت یا حالت؟ ارزیابی طولی عصب روانشناختی و مطالعات FMRI در ابتلا به اختلال اسکیزوافکتیو

کد مقاله سال انتشار مقاله انگلیسی ترجمه فارسی تعداد کلمات
72883 2014 7 صفحه PDF سفارش دهید محاسبه نشده
خرید مقاله
پس از پرداخت، فوراً می توانید مقاله را دانلود فرمایید.
عنوان انگلیسی
Trait or state? A longitudinal neuropsychological evaluation and fMRI study in schizoaffective disorder
منبع

Publisher : Elsevier - Science Direct (الزویر - ساینس دایرکت)

Journal : Schizophrenia Research, Volume 159, Issues 2–3, November 2014, Pages 458–464

کلمات کلیدی
اختلال اسکیزوافکتیو؛ بررسی طولی؛ تصویربرداری عصبی؛ کار نفر پشت؛ فاز حاد؛ بهبود بالینی؛ خصلت؛ حالت
پیش نمایش مقاله
پیش نمایش مقاله خصلت یا حالت؟ ارزیابی طولی عصب روانشناختی و مطالعات FMRI در ابتلا به اختلال اسکیزوافکتیو

چکیده انگلیسی

Schizoaffective patients can have neurocognitive deficits and default mode network dysfunction while being acutely ill. It remains unclear to what extent these abnormalities persist when they go into clinical remission. Memory and executive function were tested in 22 acutely ill schizoaffective patients; they also underwent fMRI scanning during performance of the n-back working memory test. The same measures were obtained after they had been in remission for ≥ 2 months. Twenty-two matched healthy individuals were also examined. In clinical remission, schizomanic patients showed an improvement of memory but not of executive function, while schizodepressive patients did not change in either domain. All schizoaffective patients in clinical remission showed memory and executive impairment compared to the controls. On fMRI, acutely ill schizomanic patients had reversible frontal hypo-activation when compared to clinical remission, while activation patterns in ill and remitted schizodepressive patients were similar. The whole group of schizoaffective patients in clinical remission showed a failure of de-activation in the medial frontal gyrus compared to the healthy controls. There was evidence for memory improvement and state dependent changes in activation in schizomanic patients across relapse and remission. Medial frontal failure of de-activation in remitted schizoaffective patients, which probably reflects default mode network dysfunction, appears to be a state independent feature of the illness.

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پس از پرداخت، فوراً می توانید مقاله را دانلود فرمایید.