دانلود مقاله ISI انگلیسی شماره 72926
عنوان فارسی مقاله

کلونازپام در درمان طولانی مدت بیماران مبتلا به افسردگی تک قطبی، دو قطبی و اختلال اسکیزوافکتیو

کد مقاله سال انتشار مقاله انگلیسی ترجمه فارسی تعداد کلمات
72926 2003 6 صفحه PDF سفارش دهید محاسبه نشده
خرید مقاله
پس از پرداخت، فوراً می توانید مقاله را دانلود فرمایید.
عنوان انگلیسی
Clonazepam in the long-term treatment of patients with unipolar depression, bipolar and schizoaffective disorder
منبع

Publisher : Elsevier - Science Direct (الزویر - ساینس دایرکت)

Journal : European Neuropsychopharmacology, Volume 13, Issue 2, March 2003, Pages 129–134

کلمات کلیدی
کلونازپام؛ تثبیت کننده خلق و خوی ؛ درمان نگهدارنده؛ افسردگی؛ اختلال دو قطبی؛ اختلال اسکیزوافکتیو
پیش نمایش مقاله
پیش نمایش مقاله کلونازپام در درمان طولانی مدت بیماران مبتلا به افسردگی تک قطبی، دو قطبی و اختلال اسکیزوافکتیو

چکیده انگلیسی

The value of a long-term treatment with clonazepam in the prophylaxis of affective disorder is discussed controversially in the scientific literature. Altogether there are only a few reports on the use of this compound as a mood stabilizer, most of them describing patients suffering from bipolar affective disorder. The aim of this investigation was to evaluate clonazepam as a phase prophylactic medication in affective disorder. We conducted a retrospective chart review in 34 out-patients of our lithium clinic (15 suffering from unipolar depression, 15 from bipolar disorder, four from schizoaffective disorder), who had been treated with clonazepam as a long-term medication. Clonazepam was either given as monotherapy, or as in the case of lithium non-responders, as adjunctive therapy. Patients with unipolar depression had significantly (P=0.026) less depressive episodes after initiation of treatment with clonazepam. Patients with bipolar disorder did not benefit from this therapy. Neither manic/hypomanic phases nor depressive episodes were reduced in this group of patients. Interestingly, clonazepam also reduced affective phases in our four schizoaffective patients on a trend level. Our results indicate that patients with unipolar depression may benefit from a maintenance treatment with clonazepam. Due to methodological limitations our results need to be replicated in controlled double-blind randomized clinical trials.

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