دانلود مقاله ISI انگلیسی شماره 72947
عنوان فارسی مقاله

ارتباط التهاب محیطی با شاخص توده بدن و عود افسردگی در اختلال دو قطبی

کد مقاله سال انتشار مقاله انگلیسی ترجمه فارسی تعداد کلمات
72947 2016 8 صفحه PDF سفارش دهید محاسبه نشده
خرید مقاله
پس از پرداخت، فوراً می توانید مقاله را دانلود فرمایید.
عنوان انگلیسی
Association of peripheral inflammation with body mass index and depressive relapse in bipolar disorder
منبع

Publisher : Elsevier - Science Direct (الزویر - ساینس دایرکت)

Journal : Psychoneuroendocrinology, Volume 65, March 2016, Pages 76–83

کلمات کلیدی
اختلال دو قطبی؛ شاخص توده بدن - چاقی؛ سیتوکین؛ التهاب؛ عود
پیش نمایش مقاله
پیش نمایش مقاله ارتباط التهاب محیطی با شاخص توده بدن و عود افسردگی در اختلال دو قطبی

چکیده انگلیسی

Bipolar I disorder (BD) is associated with increased inflammation, which is believed to be central to disease etiology and progression. However, BD patients also have high rates of obesity, itself an inflammatory condition, and the relative contributions of mood illness and obesity to inflammation are unknown. Moreover, the impact of inflammation on clinical illness course has not been well studied. The objectives of this analysis were therefore: (1) to determine if inflammation in BD is mood illness-related or secondary to elevated body mass index (BMI), and (2) to investigate the impact of inflammation on prospectively-ascertained relapse into depression and mania. We measured the serum levels of 7 inflammatory cytokines (TNF-α, γ-interferon, monocyte chemoattractant protein-1 [MCP-1], IL-1α, IL-2, IL-6, and IL-8) and 2 anti-inflammatory cytokines (IL-4 and IL-10) in 52 early-stage BD patients and 22 healthy subjects. In patients, a multivariate multiple regression model that controlled for psychotropic medications found that higher BMI, but not recent (past-6-month) mood episodes, predicted greater inflammatory cytokines (p = .05). Healthy subjects also had a BMI-related increase in inflammatory cytokines (p < .01), but it was counter-balanced by a compensatory increase in anti-inflammatory cytokines (p = .02), reducing their total inflammatory burden from higher BMI. In patients, linear regression showed that two inflammatory cytokines predicted depressive relapse in the 12 months after cytokine measurement: IL-1α (p < .01) and MCP-1 (p < .01). These results suggest that elevated BMI is a significant contributor to inflammation in BD, more so even than recent mood illness severity. They also point to inflammation as an important predictor of illness course, particularly depressive relapse.

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پس از پرداخت، فوراً می توانید مقاله را دانلود فرمایید.