دانلود مقاله ISI انگلیسی شماره 72980
عنوان فارسی مقاله

تحقیقات مقدماتی از بروز miRNA در افراد در معرض خطر بالای خانوادگی اختلال دو قطبی

کد مقاله سال انتشار مقاله انگلیسی ترجمه فارسی تعداد کلمات
72980 2015 8 صفحه PDF سفارش دهید محاسبه نشده
خرید مقاله
پس از پرداخت، فوراً می توانید مقاله را دانلود فرمایید.
عنوان انگلیسی
Preliminary investigation of miRNA expression in individuals at high familial risk of bipolar disorder
منبع

Publisher : Elsevier - Science Direct (الزویر - ساینس دایرکت)

Journal : Journal of Psychiatric Research, Volume 62, March 2015, Pages 48–55

کلمات کلیدی
اختلال دو قطبی؛ miRNA ها؛ نشانگر؛ بروز ژن؛ PI3K / AKT؛ GABA
پیش نمایش مقاله
پیش نمایش مقاله تحقیقات مقدماتی از بروز miRNA در افراد در معرض خطر بالای خانوادگی اختلال دو قطبی

چکیده انگلیسی

Bipolar disorder (BD) is a highly heritable psychiatric disorder characterised by recurrent episodes of mania and depression. Many studies have reported altered gene expression in BD, some of which may be attributable to the dysregulated expression of miRNAs. Studies carried out to date have largely studied medicated patients, so it is possible that observed changes in miRNA expression might be a consequence of clinical illness or of its treatment. We sought to establish whether altered miRNA expression might play a causative role in the development of BD by studying young, unmedicated relatives of individuals with BD, who are at a higher genetic risk of developing BD themselves (high-risk individuals). The expression of 20 miRNAs previously implicated in either BD or schizophrenia was measured by qRT-PCR in whole-blood samples from 34 high-risk and 46 control individuals. Three miRNAs, miR-15b, miR-132 and miR-652 were up-regulated in the high-risk individuals, consistent with previous reports of increased expression of these miRNAs in patients with schizophrenia. Our findings suggest that the altered expression of these miRNAs might represent a mechanism of genetic susceptibility for BD. Moreover, our observation of altered miRNA expression in the blood prior to the onset of illness provides hope that one day blood-based tests may aid in the risk-stratification and treatment of BD.

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