دانلود مقاله ISI انگلیسی شماره 72992
عنوان فارسی مقاله

آدیپوکینها، اختلال در سوخت و ساز بدن و دوره بیماری در اختلال دو قطبی

کد مقاله سال انتشار مقاله انگلیسی ترجمه فارسی تعداد کلمات
72992 2016 7 صفحه PDF سفارش دهید محاسبه نشده
خرید مقاله
پس از پرداخت، فوراً می توانید مقاله را دانلود فرمایید.
عنوان انگلیسی
Adipokines, metabolic dysfunction and illness course in bipolar disorder
منبع

Publisher : Elsevier - Science Direct (الزویر - ساینس دایرکت)

Journal : Journal of Psychiatric Research, Volume 74, March 2016, Pages 63–69

کلمات کلیدی
اختلال دو قطبی؛ سوخت و ساز بدن - لپتین؛ آدیپونکتین
پیش نمایش مقاله
پیش نمایش مقاله آدیپوکینها، اختلال در سوخت و ساز بدن و دوره بیماری در اختلال دو قطبی

چکیده انگلیسی

Replicated evidence indicates that individuals with BD are differentially affected by metabolic comorbidities and that its occurrence is a critical mediator and/or moderator of BD outcomes. This study aimed to explore the role of adipokines on bipolar disorder (BD) course and its relationship with metabolic comorbidities (i.e. type 2 diabetes mellitus, obesity). We measured plasma levels of adiponectin and leptin, as well as anthropometric and metabolic parameters of 59 patients with BD and 28 healthy volunteers. Our results showed that, in female participants, adiponectin was lower in individuals with BD, relative to healthy controls (p = 0.017). In the BD population, adiponectin levels were correlated with fasting glucose (r = −0.291, p = 0.047), fasting insulin (r = −0.332, p = 0.023), C-peptide (r = 0.040, p = 0.040), homeostatic model assessment-insulin resistance (r = −0.411, p = 0.004), HDL (r = 0.508, p < 0.001), VLDL (r = −0.395, p = 0.005) and triglycerides (r = −0.310, p = 0.030). After adjustment for age, gender and BMI, individuals with BD and low adiponectin levels (i.e. < 7.5 μg/ml), had a higher number of mood episodes (p < 0.001), lower number of psychiatric hospitalizations (p = 0.007), higher depressive symptoms (p < 0.001) and lower levels of functioning (p = 0.020). In conclusion, adiponectin levels, either directly or as a proxy of metabolic dysfunction, is independently associated with an unfavorable course of illness in BD.

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پس از پرداخت، فوراً می توانید مقاله را دانلود فرمایید.