دانلود مقاله ISI انگلیسی شماره 73061
عنوان فارسی مقاله

متاآنالیز به روز شده مارکرهای استرس اکسیداتیو در اختلال دو قطبی

کد مقاله سال انتشار مقاله انگلیسی ترجمه فارسی تعداد کلمات
73061 2014 8 صفحه PDF سفارش دهید محاسبه نشده
خرید مقاله
پس از پرداخت، فوراً می توانید مقاله را دانلود فرمایید.
عنوان انگلیسی
An updated meta-analysis of oxidative stress markers in bipolar disorder
منبع

Publisher : Elsevier - Science Direct (الزویر - ساینس دایرکت)

Journal : Psychiatry Research, Volume 218, Issues 1–2, 15 August 2014, Pages 61–68

کلمات کلیدی
اختلال دو قطبی؛ استرس اکسیداتیو؛ آنزیم های آنتی اکسیدان؛ پراکسیداسیون لیپیدی؛ مغز پس از مرگ
پیش نمایش مقاله
پیش نمایش مقاله متاآنالیز به روز شده مارکرهای استرس اکسیداتیو در اختلال دو قطبی

چکیده انگلیسی

Despite its debilitating symptoms, the pathophysiology of bipolar disorder (BD) remains unclear. One consistently compelling finding, however, has been the presence of oxidative stress. In the present investigation, we conducted a meta-analysis of studies that measured oxidative stress markers in BD patients compared to healthy controls. Search terms and selection criteria were determined a priori to identify and include all studies that measured a marker of oxidative stress in BD compared to healthy controls. Eight markers were included: superoxide dismutase, catalase, protein carbonyl, glutathione peroxidase, 3-nitrotyrosine, lipid peroxidation, nitric oxide, and DNA/RNA damage. A meta-analysis of standardized means was conducted using a random-effects model with generic inverse weighting. Between-study heterogeneity, publication bias, and sensitivity analyses were also examined for each marker. Twenty-seven papers were included in the meta-analysis, which comprised a total of 971 unique patients with BD and 886 healthy controls. Lipid peroxidation, DNA/RNA damage, and nitric oxide were significantly increased in BD patients compared to healthy controls. Additionally, the effect size for lipid peroxidation was very high. Publication bias was not detected for any of the markers. The main limitations in this meta-analysis are the high degree of heterogeneity between studies and the small number of studies used in the analysis of some markers. Additionally, the sensitivity analysis indicated that some results are not very robust. The results from this meta-analysis support the role of oxidative stress in bipolar disorder, especially to DNA, RNA, and lipids.

خرید مقاله
پس از پرداخت، فوراً می توانید مقاله را دانلود فرمایید.