دانلود مقاله ISI انگلیسی شماره 73269
عنوان فارسی مقاله

تحریک جریان مستقیم تکرار کرانیال هوس های غذایی در موش را کاهش می دهد

کد مقاله سال انتشار مقاله انگلیسی ترجمه فارسی تعداد کلمات
73269 2016 9 صفحه PDF سفارش دهید محاسبه نشده
خرید مقاله
پس از پرداخت، فوراً می توانید مقاله را دانلود فرمایید.
عنوان انگلیسی
Repeated transcranial direct current stimulation reduces food craving in Wistar rats
منبع

Publisher : Elsevier - Science Direct (الزویر - ساینس دایرکت)

Journal : Appetite, Volume 103, 1 August 2016, Pages 29–37

کلمات کلیدی
هوس های غذایی؛ مواد غذایی خوش طعم - قشر جلوی مغز؛ تحریک جریان مستقیم ترانس کرانیال
پیش نمایش مقاله
پیش نمایش مقاله تحریک جریان مستقیم تکرار کرانیال هوس های غذایی در موش را کاهش می دهد

چکیده انگلیسی

It has been suggested that food craving—an intense desire to consume a specific food (particularly foods high in sugar and fat)—can lead to obesity. This behavior has also been associated with abuse of other substances, such as drugs. Both drugs and food cause dependence by acting on brain circuitry involved in reward, motivation, and decision-making processes. The dorsolateral prefrontal cortex (DLPFC) can be activated following evocation and is implicated in alterations in food behavior and craving. Transcranial direct current stimulation (tDCS), a noninvasive brain stimulation technique capable of modulates brain activity significantly, has emerged as a promising treatment to inhibit craving. This technique is considered safe and inexpensive; however, there is scant research using animal models. Such studies could help elucidate the behavioral and molecular mechanisms of eating disorders, including food craving. The aim of our study was to evaluate palatable food consumption in rats receiving tDCS treatment (anode right/cathode left). Eighteen adult male Wistar rats were randomized by weight and divided into three groups (n = 6/group): control, with no stimulation; sham, receiving daily 30 s tDCS (500 μA) sessions for 8 consecutive days; and tDCS, receiving daily 20 min tDCS (500 μA) sessions for 8 consecutive days. All rats were evaluated for locomotor activity and anxiety-like behavior. A palatable food consumption test was performed at baseline and on treatment completion (24 h after the last tDCS session) under fasting and feeding conditions and showed that tDCS decreased food craving, thus corroborating human studies. This result confirms the important role of the prefrontal cortex in food behavior, which can be modulated by noninvasive brain stimulation.

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