دانلود مقاله ISI انگلیسی شماره 73466
عنوان فارسی مقاله

تغییرات گلوتامات های منطقه ای در بیماران مبتلا به افسردگی تک قطبی

کد مقاله سال انتشار مقاله انگلیسی ترجمه فارسی تعداد کلمات
73466 2012 7 صفحه PDF سفارش دهید 4210 کلمه
خرید مقاله
پس از پرداخت، فوراً می توانید مقاله را دانلود فرمایید.
عنوان انگلیسی
Region-specific glutamate changes in patients with unipolar depression
منبع

Publisher : Elsevier - Science Direct (الزویر - ساینس دایرکت)

Journal : Journal of Psychiatric Research, Volume 46, Issue 8, August 2012, Pages 1059–1065

کلمات کلیدی
افسردگی؛ گلوتامات؛ DLPFC؛ قشر کمربندی؛ پیش بینی پاسخ
پیش نمایش مقاله
پیش نمایش مقاله تغییرات گلوتامات های منطقه ای در بیماران مبتلا به افسردگی تک قطبی

چکیده انگلیسی

The present study aimed to investigate glutamate concentrations in patients with unipolar depression in the midcingulate cortex (MCC) as compared to the left dorsolateral prefrontal cortex (DLPFC). We hypothesized a dissociation of glutamate levels with unchanged levels in DLPFC and abnormally changed levels in MCC as well as differential effects of antidepressant pharmacotherapy. Glutamate was determined using magnetic resonance spectroscopy at 3 T in DLPFC and MCC in fourteen depressed patients and matched healthy volunteers. A follow-up measurement was performed after 4 weeks of antidepressant treatment. The main finding is a region-specific pattern of glutamate concentrations with increased MCC glutamate concentrations and no significant differences in DLPFC glutamate concentrations in unipolar depressive patients compared to healthy controls. Response and non-response to antidepressant pharmacotherapy were predicted by high glutamate at baseline in DLPFC and MCC, respectively. In addition, treatment responders showed a further increase in DLPFC glutamate levels after successful antidepressant treatment. Findings indicate altered region-specific glutamate concentrations in DLPFC and MCC that are predictive of response and non-response, respectively, to antidepressant pharmacotherapy. These findings might serve as a starting point for future studies in which the value of this metabolite pattern for treatment response prediction should be investigated.

خرید مقاله
پس از پرداخت، فوراً می توانید مقاله را دانلود فرمایید.