دانلود مقاله ISI انگلیسی شماره 73468
عنوان فارسی مقاله

عامل نوروتروفیک مشتق از مغز سرم در افسردگی دو قطبی و افسردگی تک قطبی: یک ابزار بالقوه کمکی برای تشخیص افتراقی

کد مقاله سال انتشار مقاله انگلیسی ترجمه فارسی تعداد کلمات
73468 2009 5 صفحه PDF سفارش دهید محاسبه نشده
خرید مقاله
پس از پرداخت، فوراً می توانید مقاله را دانلود فرمایید.
عنوان انگلیسی
Serum brain-derived neurotrophic factor in bipolar and unipolar depression: A potential adjunctive tool for differential diagnosis
منبع

Publisher : Elsevier - Science Direct (الزویر - ساینس دایرکت)

Journal : Journal of Psychiatric Research, Volume 43, Issue 15, October 2009, Pages 1200–1204

کلمات کلیدی
اختلال دو قطبی؛ اختلال افسردگی اساسی - BDNF؛ نشانگر تشخیصی؛ افسردگی
پیش نمایش مقاله
پیش نمایش مقاله عامل نوروتروفیک مشتق از مغز سرم در افسردگی دو قطبی و افسردگی تک قطبی: یک ابزار بالقوه کمکی برای تشخیص افتراقی

چکیده انگلیسی

The differential diagnosis of Bipolar Disorder (BD) and Major Depressive Disorder (MDD) is a diagnostic challenge during depressive episodes. Noteworthy, the proper differentiation between BD depressive state and MDD has important treatment implications. BDNF levels may be valuable adjunctive tool for this differential diagnosis. Ten subjects with MDD, forty with BD type I and thirty healthy comparison subjects were recruited. All subjects had BDNF serum levels measured and, in patients, BDNF serum levels were assessed during acute depressive episode. Optimal sensitivity and specificity of serum BDNF for the differential diagnosis of unipolar and bipolar depression were determined by the receiver operating characteristic (ROC) curve analysis, using a nonparametric approach. Serum BDNF levels in depressive BD patients were lower compared to MDD patients and controls (0.15 ± 0.08, 0.35 ± 0.08, and 0.38 ± 0.12, respectively, p < 0.001). The area under the curve (AUC) of the ROC analysis in BD depression vs. MDD was 0.95 (ranged from 0.89 to 1.00). Overall, the AUC of the ROC analysis (BD depression vs. MDD and controls) was 0.94 (95% CI 0.89 to 0.99, p < 0.001). A proposed “best” cutoff of 0.26 resulted in 88% sensitivity and 90% specificity. Serum BDNF levels appear as a promising tool to discriminate bipolar from unipolar depression. Our results suggest the role of BDNF as an adjunctive tool to promote prompt and accurate diagnosis of BD. However, further investigation and replication of these results are warranted.

خرید مقاله
پس از پرداخت، فوراً می توانید مقاله را دانلود فرمایید.