دانلود مقاله ISI انگلیسی شماره 73510
عنوان فارسی مقاله

پاسخ پرولاکتین به تجویز فنفلورامین در بیماران مبتلا به افسردگی تک قطبی و دو قطبی و افراد سالم

کد مقاله سال انتشار مقاله انگلیسی ترجمه فارسی تعداد کلمات
73510 2003 15 صفحه PDF سفارش دهید محاسبه نشده
خرید مقاله
پس از پرداخت، فوراً می توانید مقاله را دانلود فرمایید.
عنوان انگلیسی
Prolactin response to fenfluramine administration in patients with unipolar and bipolar depression and healthy controls
منبع

Publisher : Elsevier - Science Direct (الزویر - ساینس دایرکت)

Journal : Psychoneuroendocrinology, Volume 28, Issue 4, May 2003, Pages 559–573

کلمات کلیدی
اختلال افسردگی اساسی - اختلال دو قطبی؛ فن فلورامین؛ پرولاکتین - سروتونین
پیش نمایش مقاله
پیش نمایش مقاله پاسخ پرولاکتین به تجویز فنفلورامین در بیماران مبتلا به افسردگی تک قطبی و دو قطبی و افراد سالم

چکیده انگلیسی

The hormonal response to the serotonin releasing agent/uptake inhibitor fenfluramine has been used as an indicator of central serotonin system function. The serotonergic system plays an important role in the etiology and pathogenesis of mood disorders. We compared the prolactin response to fenfluramine administration in unipolar depressed patients (major depressive disorder), depressed patients with bipolar disorder, and healthy controls. We found a trend towards a blunted prolactin response in depressed patients compared to healthy controls, after controlling for sex, family history, family history-by-gender interaction, and baseline levels. There was no significant difference between unipolar and bipolar patients in the baseline prolactin levels or the response to the fenfluramine administration. We also found a negative correlation between aggression and impulsivity scores and prolactin responses in subgroup with unipolar but not bipolar depression. Female patients with unipolar depression who had first-degree relatives with unipolar depression and normal controls had significantly higher prolactin responses than female patients with unipolar depression who did not have first-degree relatives with unipolar depression. The lack of difference in the response to fenfluramine administration between unipolar and bipolar depressed patients may indicate that overall serotonergic function in unipolar and bipolar depressed patients is similarly impaired.

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پس از پرداخت، فوراً می توانید مقاله را دانلود فرمایید.