دانلود مقاله ISI انگلیسی شماره 74364
عنوان فارسی مقاله

مهار تغییر احساسات منفی در افراد در معرض خطر اختلال افسردگی اساسی خانوادگی

کد مقاله سال انتشار مقاله انگلیسی ترجمه فارسی تعداد کلمات
74364 2012 8 صفحه PDF سفارش دهید محاسبه نشده
خرید مقاله
پس از پرداخت، فوراً می توانید مقاله را دانلود فرمایید.
عنوان انگلیسی
Altered inhibition of negative emotions in subjects at family risk of major depressive disorder ☆
منبع

Publisher : Elsevier - Science Direct (الزویر - ساینس دایرکت)

Journal : Journal of Psychiatric Research, Volume 46, Issue 2, February 2012, Pages 181–188

کلمات کلیدی
اختلال افسردگی اساسی - آسیب پذیری؛ ریسک بالا؛ تاثیر پذیری بستگان درجه اول؛ مهار اطلاعات عاطفی
پیش نمایش مقاله
پیش نمایش مقاله مهار تغییر احساسات منفی در افراد در معرض خطر اختلال افسردگی اساسی خانوادگی

چکیده انگلیسی

Unaffected 1st degree relatives of patients with major depressive disorder (MDD) are more likely to develop MDD than healthy controls. The aim of our study was to establish neuronal correlates of familial susceptibility in the process of inhibition of emotional information. Unaffected 1st degree relatives of patients with MDD (N = 21) and matched healthy controls (N = 25) underwent a functional magnetic resonance imaging procedure with an inhibition task. Blood oxygenated level dependent signal was evaluated for the two groups during inhibition of positive, negative and neutral information. In a 2 × 3 ANOVA unaffected relatives of patients with MDD were compared to healthy controls, jointly and separately for all three levels of emotional valence of the information. The interaction between group and emotional valence of the inhibited information was significant, indicating “a negative neural drift” in unaffected relatives of patients with MDD. The unaffected relatives of patients with MDD displayed an increased activation during inhibiting of negative material in the right middle cingulate cortex and the left caudate nucleus (p < 0.05, family wise error corrected). There was no difference between the two groups in terms of inhibiting positive or neutral stimuli. Our findings provide the first evidence that unaffected relatives of patients with MDD differ from the standard population in terms of neural correlates of inhibition of negative emotional information. Overactivation of cingulate cortex and caudate nucleus may indicate a learnt strategy aimed at coping with increased susceptibility to negative information schemata and may have future consequences for therapy.

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