دانلود مقاله ISI انگلیسی شماره 74366
عنوان فارسی مقاله

مصرف کنندگان کوکائین با اختلال شخصیتی همراه خوشه B فعالیت مغزی ناکارآمد و اتصال در شبکه های تنظیم هیجان در طول نگهداری احساسات منفی و ارزیابی مجدد را نشان می دهند

کد مقاله سال انتشار مقاله انگلیسی ترجمه فارسی تعداد کلمات
74366 2013 10 صفحه PDF سفارش دهید محاسبه نشده
خرید مقاله
پس از پرداخت، فوراً می توانید مقاله را دانلود فرمایید.
عنوان انگلیسی
Cocaine users with comorbid Cluster B personality disorders show dysfunctional brain activation and connectivity in the emotional regulation networks during negative emotion maintenance and reappraisal
منبع

Publisher : Elsevier - Science Direct (الزویر - ساینس دایرکت)

Journal : European Neuropsychopharmacology, Volume 23, Issue 12, December 2013, Pages 1698–1707

کلمات کلیدی
کوکائین؛ اختلال شخصیت مرزی؛ اختلال شخصیت نمایشی؛ اختلال شخصیت ضد اجتماعی؛ احساسات منفی - ارزیابی مجدد؛ قشر کمربندی قدامی؛ آمیگدال
پیش نمایش مقاله
پیش نمایش مقاله مصرف کنندگان کوکائین با اختلال شخصیتی همراه خوشه B فعالیت مغزی ناکارآمد و اتصال در شبکه های تنظیم هیجان در طول نگهداری احساسات منفی و ارزیابی مجدد را نشان می دهند

چکیده انگلیسی

Cocaine dependence often co-occurs with Cluster B personality disorders. Since both disorders are characterized by emotion regulation deficits, we predicted that cocaine comorbid patients would exhibit dysfunctional patterns of brain activation and connectivity during reappraisal of negative emotions. We recruited 18 cocaine users with comorbid Cluster B personality disorders, 17 cocaine users without comorbidities and 21 controls to be scanned using functional magnetic resonance imaging (fMRI) during performance on a reappraisal task in which they had to maintain or suppress the emotions induced by negative affective stimuli. We followed region of interest (ROI) and whole-brain approaches to investigate brain activations and connectivity associated with negative emotion experience and reappraisal. Results showed that cocaine users with comorbid personality disorders had reduced activation of the subgenual anterior cingulate cortex during negative emotion maintenance and increased activation of the lateral orbitofrontal cortex and the amygdala during reappraisal. Amygdala activation correlated with impulsivity and antisocial beliefs in the comorbid group. Connectivity analyses showed that in the cocaine comorbid group the subgenual cingulate was less efficiently connected with the amygdala and the fusiform gyri and more efficiently connected with the anterior insula during maintenance, whereas during reappraisal the left orbitofrontal cortex was more efficiently connected with the amygdala and the right orbitofrontal cortex was less efficiently connected with the dorsal striatum. We conclude that cocaine users with comorbid Cluster B personality disorders have distinctive patterns of brain activation and connectivity during maintenance and reappraisal of negative emotions, which correlate with impulsivity and dysfunctional beliefs.

خرید مقاله
پس از پرداخت، فوراً می توانید مقاله را دانلود فرمایید.