دانلود مقاله ISI انگلیسی شماره 74383
عنوان فارسی مقاله

انفصال های فرونتو-لیمبیک و اتونوم به تشخیص زیرگروه اسکیزوفرنی هیجانات منفی

کد مقاله سال انتشار مقاله انگلیسی ترجمه فارسی تعداد کلمات
74383 2007 16 صفحه PDF سفارش دهید محاسبه نشده
خرید مقاله
پس از پرداخت، فوراً می توانید مقاله را دانلود فرمایید.
عنوان انگلیسی
Fronto-limbic and autonomic disjunctions to negative emotion distinguish schizophrenia subtypes
منبع

Publisher : Elsevier - Science Direct (الزویر - ساینس دایرکت)

Journal : Psychiatry Research: Neuroimaging, Volume 155, Issue 1, 15 May 2007, Pages 29–44

کلمات کلیدی
اسکیزوفرنی؛ پاسخ رسانایی پوست؛ احساسات منفی - خشم ترس و انزجار؛ آمیگدال؛ قشر جلو مغزی میانی
پیش نمایش مقاله
پیش نمایش مقاله انفصال های فرونتو-لیمبیک و اتونوم به تشخیص زیرگروه اسکیزوفرنی هیجانات منفی

چکیده انگلیسی

Schizophrenia patients show a disconnection in amygdala-medial prefrontal cortex and autonomic arousal systems for processing fear. Concurrent functional magnetic resonance imaging [fMRI] and skin conductance recording were used to determine whether these disturbances are specific to fear, or present in response to other signals of danger. We also examined whether these disturbances distinguish a specific symptom profile. During scanning, 27 schizophrenia (13 paranoid, 14 nonparanoid) and 22 matched healthy control subjects viewed standardized facial expressions of fear, anger and disgust (versus neutral). Skin conductance responses [SCRs]were acquired simultaneously to assess phasic increases in arousal. ‘With-arousal’ versus ‘without-arousal’ responses were analysed using non-parametric methods. For controls, ‘with-arousal’ responses were associated with emotion-specific activity for fear (amygdala), disgust (insula) and anger (anterior cingulate), together with common medial prefrontal cortex [MPFC] engagement, as predicted. Schizophrenia patients displayed abnormally increased phasic arousal, with concomitant reductions in emotion-specific regions and MPFC. These findings may reflect a general disconnection between central and autonomic systems for processing signals of danger. This disjunction was most apparent in patients with a profile of paranoia, coupled with poor social function and insight. Heightened autonomic sensitivity to signals of fear, threat or contamination, without effective neural mechanisms for appraisal, may underlie paranoid delusions which concern threat and contamination, and associated social and interpersonal difficulties.

خرید مقاله
پس از پرداخت، فوراً می توانید مقاله را دانلود فرمایید.