دانلود مقاله ISI انگلیسی شماره 74519
عنوان فارسی مقاله

اختلال احتکار و اختلال وسواس اجباری الگوهای مختلف فعالیت عصبی در طول بازداری پاسخ را نشان می دهند

کد مقاله سال انتشار مقاله انگلیسی ترجمه فارسی تعداد کلمات
74519 2014 7 صفحه PDF سفارش دهید محاسبه نشده
خرید مقاله
پس از پرداخت، فوراً می توانید مقاله را دانلود فرمایید.
عنوان انگلیسی
Hoarding disorder and obsessive–compulsive disorder show different patterns of neural activity during response inhibition
منبع

Publisher : Elsevier - Science Direct (الزویر - ساینس دایرکت)

Journal : Psychiatry Research: Neuroimaging, Volume 221, Issue 2, 28 February 2014, Pages 142–148

کلمات کلیدی
احتکار؛ اختلال وسواس اجباری؛ تصویربرداری عصبی؛ تصویربرداری رزونانس مغناطیسی عملکردی (fMRI) ؛ بازداری
پیش نمایش مقاله
پیش نمایش مقاله اختلال احتکار و اختلال وسواس اجباری الگوهای مختلف فعالیت عصبی در طول بازداری پاسخ را نشان می دهند

چکیده انگلیسی

Although hoarding disorder (HD) has been historically conceptualized as a subtype or dimension of obsessive–compulsive disorder (OCD), preliminary evidence suggests that these two disorders have distinct neural underpinnings. The aim of the present study was to compare the hemodynamic responses of HD patients, OCD patients, and healthy controls (HC) during response inhibition on a high-conflict Go/NoGo task that has previously proved sensitive to OCD. Participants comprised 24 HD patients, 24 OCD patients, and 24 HCs who completed a Go/NoGo task during functional magnetic resonance imaging (fMRI). Although behavioral data showed no difference among the groups in Go/NoGo task performance, significant differences in hemodynamic activity were noted. During correct rejects (successful response inhibition), HD patients showed greater right precentral gyrus activation, whereas OCD patients exhibited greater right orbitofrontal activation, as assessed using a region of interest approach. During errors of commission (response inhibition failures), OCD patients, but not HD patients, were characterized by excessive activity in left and right orbitofrontal gyrus. The present results lend further support to the biological distinction between HD and OCD, and they are consistent with previous research suggesting frontal hypoactivity in HD patients during hoarding-unrelated tasks.

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