دانلود مقاله ISI انگلیسی شماره 74764
عنوان فارسی مقاله

تاثیر درد در غیاب احساس درد: مدارک و شواهد از استفاده از داروی بیهوشی ضایعات قشر حساسیت جسمی در موش صحرایی

کد مقاله سال انتشار مقاله انگلیسی ترجمه فارسی تعداد کلمات
74764 2012 8 صفحه PDF سفارش دهید محاسبه نشده
خرید مقاله
پس از پرداخت، فوراً می توانید مقاله را دانلود فرمایید.
عنوان انگلیسی
Pain affect in the absence of pain sensation: Evidence of asomaesthesia after somatosensory cortex lesions in the rat
منبع

Publisher : Elsevier - Science Direct (الزویر - ساینس دایرکت)

Journal : PAIN®, Volume 153, Issue 4, April 2012, Pages 885–892

کلمات کلیدی
قشر حساسیت جسمی؛ پردازش درد حسی؛ پردازش درد عاطفی؛ آستانه خروج پنجه؛ کامل ادجوانت فروند،
پیش نمایش مقاله
پیش نمایش مقاله تاثیر درد در غیاب احساس درد: مدارک و شواهد از استفاده از داروی بیهوشی ضایعات قشر حساسیت جسمی در موش صحرایی

چکیده انگلیسی

Multidimensional models of pain processing distinguish the sensory, motivational, and affective components of the pain experience. Efforts to understand underlying mechanisms have focused on isolating the roles of specific brain structures, including both limbic and non-limbic cortical areas, in the processing of nociceptive stimuli. The purpose of this study was to examine the role of the somatosensory cortex in both sensory and affective aspects of pain processing. It was hypothesized that animals with lesions of the hind limb area of the somatosensory cortex would demonstrate altered sensory processing (asomaesthesia, a deficit in the ability to detect and identify somatic sensation) in the presence of an inflammatory state when compared to animals with sham lesions. The level of pain affect produced by an inflammatory pain condition was not expected to change, as this region has not demonstrated a role in processing the affective component of pain. Seventy-nine adult female Sprague-Dawley rats were randomly assigned to receive bilateral lesions or a sham procedure. The results showed that somatosensory lesions to the hindlimb region altered responses to mechanical stimulation in the presence of experimentally-induced inflammation, but did not attenuate the inflammation-induced paw volume changes or the level of pain affect, as demonstrated by escape/avoidance behavior in response to mechanical stimulation. Overall, these results support previous evidence suggesting that the somatosensory cortex is primarily involved in the processing the sensory/discriminative aspect of pain, and the current study is the first to demonstrate the presence of pain affect in the absence of somatosensory processing.

خرید مقاله
پس از پرداخت، فوراً می توانید مقاله را دانلود فرمایید.