دانلود مقاله ISI انگلیسی شماره 74875
عنوان فارسی مقاله

کورتیزول بزاق در ناسازگاری بی تاثیر دوقلوها برای اختلال عاطفی

کد مقاله سال انتشار مقاله انگلیسی ترجمه فارسی تعداد کلمات
74875 2008 10 صفحه PDF سفارش دهید محاسبه نشده
خرید مقاله
پس از پرداخت، فوراً می توانید مقاله را دانلود فرمایید.
عنوان انگلیسی
Salivary cortisol in unaffected twins discordant for affective disorder
منبع

Publisher : Elsevier - Science Direct (الزویر - ساینس دایرکت)

Journal : Psychiatry Research, Volume 161, Issue 3, 15 December 2008, Pages 292–301

کلمات کلیدی
کورتیزول؛ اختلالات خلقی؛ مطالعه در معرض خطر
پیش نمایش مقاله
پیش نمایش مقاله کورتیزول بزاق در ناسازگاری بی تاثیر دوقلوها برای اختلال عاطفی

چکیده انگلیسی

Dysfunction in the hypothalamic–pituitary–adrenal (HPA) axis has been proposed as a biological endophenotype for affective disorders. In the present study the hypothesis that a high genetic liability to affective disorder is associated with higher cortisol levels was tested in a cross-sectional high-risk study. Healthy monozygotic (MZ) and dizygotic (DZ) twins with (High-Risk twins) and without (Low-Risk twins) a co-twin history of affective disorder were identified through nationwide registers. Awakening and evening salivary cortisol levels were compared between the 190 High- and Low-Risk twins. The 109 High-Risk twins had significantly higher evening cortisol levels than the 81 Low-Risk MZ twins, also after adjustment for age, sex, and the level of subclinical depressive symptoms. No significant difference was found in awakening cortisol levels between High-Risk and Low-Risk twins. In conclusion, a high genetic liability to affective disorder was associated with a higher evening cortisol level, but not with awakening cortisol level. Future prospective family, high-risk and twin studies are needed to decide whether abnormalities in the HPA axis can be identified as an endophenotype of affective disorder.

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پس از پرداخت، فوراً می توانید مقاله را دانلود فرمایید.