دانلود مقاله ISI انگلیسی شماره 74878
عنوان فارسی مقاله

تفاوت سازگار در حجم ماده خاکستری بین افراد مبتلا به فیبرومیالژیا و افراد سالم همسن در هنگام کنترل برای اختلال عاطفی

کد مقاله سال انتشار مقاله انگلیسی ترجمه فارسی تعداد کلمات
74878 2009 6 صفحه PDF سفارش دهید محاسبه نشده
خرید مقاله
پس از پرداخت، فوراً می توانید مقاله را دانلود فرمایید.
عنوان انگلیسی
No consistent difference in gray matter volume between individuals with fibromyalgia and age-matched healthy subjects when controlling for affective disorder
منبع

Publisher : Elsevier - Science Direct (الزویر - ساینس دایرکت)

Journal : PAIN®, Volume 143, Issue 3, June 2009, Pages 262–267

کلمات کلیدی
فیبرومیالژیا؛ وکسل مبتنی بر مورفومتری - ماده خاکستری؛ افسردگی؛ درد
پیش نمایش مقاله
پیش نمایش مقاله تفاوت سازگار در حجم ماده خاکستری بین افراد مبتلا به فیبرومیالژیا و افراد سالم همسن در هنگام کنترل برای اختلال عاطفی

چکیده انگلیسی

Fibromyalgia (FM) is thought to involve abnormalities in central pain processing. Recent studies involving small samples have suggested alterations in gray matter volume (GMV) in brains of FM patients. Our objective was to verify these findings in a somewhat larger sample using voxel-based morphometry (VBM), while controlling for the presence of affective disorders (AD). T1-weighted magnetic resonance image (MRI) brain scans were obtained on 29 FM patients with AD, 29 FM patients without AD, and 29 age-matched healthy controls (HCs) using a 3T scanner. Segmentation, spatial normalization, and volumetric modulation were performed using an automated protocol within SPM5. Smoothed gray matter segments were entered into a voxel-wise one-way ANOVA, and a search for significant clusters was performed using thresholding methods published in previous studies (whole-brain threshold of p < .05 correcting for multiple comparisons; region-of-interest (ROI) threshold of p ⩽ .001 uncorrected, or p < .05 small-volume corrected). The whole-brain analysis did not reveal any significant clusters. ROI-based analysis revealed a significant difference in left anterior insula GMV among the three groups (xyz = {−28, 21, 9}; p = .026, corrected). However, on post-hoc testing, FM patients without AD did not differ significantly from HC with respect to mean GMV extracted from this cluster. A significant negative correlation was found between mean cluster GMV and scores of trait anxiety (State-Trait Personality Inventory, Trait Anxiety scale; rho = −.470, p < .001). No other significant clusters were found on ROI-based analysis. Our results emphasize the importance of correcting for AD when carrying out VBM studies in chronic pain.

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پس از پرداخت، فوراً می توانید مقاله را دانلود فرمایید.