دانلود مقاله ISI انگلیسی شماره 75117
عنوان فارسی مقاله

سیستم هورمون استرس در اختلالات مختلف خواب

کد مقاله سال انتشار مقاله انگلیسی ترجمه فارسی تعداد کلمات
75117 2011 6 صفحه PDF سفارش دهید 4450 کلمه
خرید مقاله
پس از پرداخت، فوراً می توانید مقاله را دانلود فرمایید.
عنوان انگلیسی
The stress hormone system in various sleep disorders
منبع

Publisher : Elsevier - Science Direct (الزویر - ساینس دایرکت)

Journal : Journal of Psychiatric Research, Volume 45, Issue 9, September 2011, Pages 1223–1228

کلمات کلیدی
خواب؛ محور هیپوتالاموس هیپوفیز آدرنال؛ حساسیت بازخورد منفی؛ سندرم آپنه انسدادی خواب؛ سندرم پاهای بی قرار؛ بی خوابی اولیه
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چکیده انگلیسی

Hypothalamic-pituitary-adrenal (HPA)-system activity is regulated by the suprachiasmatic nucleus, the primary endogenous circadian pacemaker. In addition, sleep plays an important modulatory role. However, data on HPA-system activity in sleep disorders are quite conflicting. A sensitive challenge test to assess negative feedback sensitivity of the HPA-system like the dexamethasone/corticotropin-releasing-hormone (DEX/CRH)-test has never been used so far in sleep disorders. Therefore we studied 25 obstructive sleep apnea (OSA) patients, 18 restless legs syndrome (RLS) patients, 21 patients with primary insomnia and compared them to 33 healthy controls. The dynamic response of the HPA-system was assessed by the DEX/CRH-test which combines suppression (dexamethasone) and stimulation (CRH) of the stress hormone system. After HPA-axis suppression the number of non-suppressors did not differ among groups indicating normal negative feedback sensitivity. In RLS patients ACTH levels were slightly lower compared to controls while cortisol levels were similar between groups. Following CRH stimulation we did not detect differences in ACTH- or cortisol levels and adrenocortical responsitivity to ACTH was comparable between groups. These results for the first time document normal HPA-system feedback sensitivity in various sleep disorders and suggest that abnormalities of the stress hormone system in affective disorders are unlikely due to concomitant sleep problems.

خرید مقاله
پس از پرداخت، فوراً می توانید مقاله را دانلود فرمایید.