دانلود مقاله ISI انگلیسی شماره 75210
عنوان فارسی مقاله

سیگنالدهی جوجه تیغی صوتی، نوروژنز آمیگدال و انقراض حافظه ترس را تنظیم می کند

کد مقاله سال انتشار مقاله انگلیسی ترجمه فارسی تعداد کلمات
75210 2015 10 صفحه PDF سفارش دهید محاسبه نشده
خرید مقاله
پس از پرداخت، فوراً می توانید مقاله را دانلود فرمایید.
عنوان انگلیسی
Sonic hedgehog signaling regulates amygdalar neurogenesis and extinction of fear memory
منبع

Publisher : Elsevier - Science Direct (الزویر - ساینس دایرکت)

Journal : European Neuropsychopharmacology, Volume 25, Issue 10, October 2015, Pages 1723–1732

کلمات کلیدی
نوروژنز؛ آمیگدال؛ جوجه تیغی صوتی؛ انقراض؛ شرطی سازی ترس
پیش نمایش مقاله
پیش نمایش مقاله سیگنالدهی جوجه تیغی صوتی، نوروژنز آمیگدال و انقراض حافظه ترس را تنظیم می کند

چکیده انگلیسی

It is now recognized that neurogenesis occurs throughout life predominantly in the subgranular zone (SGZ) of the hippocampus and the subventricular zone (SVZ) of the lateral ventricle. In the present study, we investigated the relationship between neurogenesis in the amygdala and extinction of fear memory. Mice received 15 tone-footshock pairings. Twenty-four hours after training, the mice were given 15 tone-alone trials (extinction training) once per day for 7 days. Two hours before extinction training, the mice were injected intraperitoneally with 5-bromo-3-deoxyuridine (BrdU). BrdU-positive and NeuN-positive cells were analyzed 52 days after the training. A group of mice that received tone-footshock pairings but no extinction training served as controls (FC+No-Ext). The number of BrdU+/NeuN+ cells was significantly higher in the extinction (FC+Ext) than in the FC+No-Ext mice. Proliferation inhibitor methylazoxymethanol acetate (MAM) or DNA synthesis inhibitor cytosine arabinoside (Ara-C) reduced neurogenesis and retarded extinction. Silencing Sonic hedgehog (Shh) gene with short hairpin interfering RNA (shRNA) by means of a retrovirus expression system to knockdown Shh specifically in the mitotic neurons reduced neurogenesis and retarded extinction. By contrast, over-expression of Shh increased neurogenesis and facilitated extinction. These results suggest that amygdala neurogenesis and Shh signaling are involved in the extinction of fear memory.

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